| Fertility after uterine artery embolization: investigation using a sheep model. | |
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MedLine Citation:
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PMID: 19949190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the influence of uterine artery embolization (UAE) on fertility after bilateral UAE with either tris-acryl gelatin microspheres (TAGM) or gelatin particles (GP). MATERIALS AND METHODS: Six ewes that underwent UAE with TAGM, 6 ewes that underwent UAE with GP, and 6 control ewes were compared. After hormonal synchronization of the menstrual cycle, artificial insemination (AI) was performed. When pregnancy did not result, ewes were naturally inseminated. RESULTS: After AI, progesterone concentrations in blood increased and were maintained at >1.0 ng/mL in 9 ewes (3 per group). Three ewes became pregnant after AI. The abortion rate was higher in the UAE group. The remaining 15 sheep were naturally inseminated, with 14 delivering 15 lambs. Mean period of term gestation in UAE group ewes was 155.7 versus 158.6 days in control group ewes. Lambs' body weight, body length, and withers height after birth did not differ between those from UAE group and control group. Lambs from ewes embolized with GP tended to be smaller and had lower body weight than those from other groups. CONCLUSION: Uterine artery embolization influenced reproductive ability in sheep and UAE with GP could lead to intrauterine growth retardation. |
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Authors:
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Takuji Yamagami; Rika Yoshimatsu; Tomohiro Matsumoto; Hiroshi Anzai; Masahiro Yoshizawa; Yutaka Fukui; Tsunehiko Nishimura |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-30 |
Journal Detail:
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Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 17 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-06-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
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Languages: eng Pagination: 350-7 Citation Subset: IM |
Affiliation:
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Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo, Kyoto, Japan. yamagami@koto.kpu-m.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acrylic Resins
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administration & dosage Animals Disease Models, Animal Female Fetal Growth Retardation / blood, etiology* Gelatin / administration & dosage Infertility, Female / blood, etiology* Pregnancy Sheep Uterine Artery Embolization / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Acrylic Resins; 0/trisacryl gelatin microspheres; 9000-70-8/Gelatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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