Document Detail

Fertility after uterine artery embolization: investigation using a sheep model.
MedLine Citation:
PMID:  19949190     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the influence of uterine artery embolization (UAE) on fertility after bilateral UAE with either tris-acryl gelatin microspheres (TAGM) or gelatin particles (GP). MATERIALS AND METHODS: Six ewes that underwent UAE with TAGM, 6 ewes that underwent UAE with GP, and 6 control ewes were compared. After hormonal synchronization of the menstrual cycle, artificial insemination (AI) was performed. When pregnancy did not result, ewes were naturally inseminated. RESULTS: After AI, progesterone concentrations in blood increased and were maintained at >1.0 ng/mL in 9 ewes (3 per group). Three ewes became pregnant after AI. The abortion rate was higher in the UAE group. The remaining 15 sheep were naturally inseminated, with 14 delivering 15 lambs. Mean period of term gestation in UAE group ewes was 155.7 versus 158.6 days in control group ewes. Lambs' body weight, body length, and withers height after birth did not differ between those from UAE group and control group. Lambs from ewes embolized with GP tended to be smaller and had lower body weight than those from other groups. CONCLUSION: Uterine artery embolization influenced reproductive ability in sheep and UAE with GP could lead to intrauterine growth retardation.
Takuji Yamagami; Rika Yoshimatsu; Tomohiro Matsumoto; Hiroshi Anzai; Masahiro Yoshizawa; Yutaka Fukui; Tsunehiko Nishimura
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-30
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  17     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  350-7     Citation Subset:  IM    
Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo, Kyoto, Japan.
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MeSH Terms
Acrylic Resins / administration & dosage
Disease Models, Animal
Fetal Growth Retardation / blood,  etiology*
Gelatin / administration & dosage
Infertility, Female / blood,  etiology*
Uterine Artery Embolization / adverse effects*
Reg. No./Substance:
0/Acrylic Resins; 0/trisacryl gelatin microspheres; 9000-70-8/Gelatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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