Document Detail

Fertilisation and pregnancy outcome after ICSI in globozoospermic patients without assisted oocyte activation.
MedLine Citation:
PMID:  19143732     Owner:  NLM     Status:  MEDLINE    
The successful outcome of intracytoplasmic sperm injection (ICSI) with globozoospermic sperm and non-activated oocytes is reported. Three couples underwent ICSI treatment and two of the patients were siblings. Forty-four non-activated oocytes were injected, 26 oocytes fertilised normally and 17 good quality embryos were obtained. Six embryo transfers were carried out, three with fresh embryos and three with frozen-thawed embryos. Three pregnancies resulted from the fresh embryo transfers and additionally two pregnancies were obtained after the transfer of frozen-thawed embryos. Two healthy babies were born. One twin pregnancy is ongoing. Our case reports demonstrate that in some ICSI attempts undertaken with globozoospermic sperm cells from two of our patients, high fertilisation rates, pregnancies and live births can be achieved, without artificially activated oocytes. Our data also suggest that in some cases, round-headed spermatozoa lack the capacity to activate the oocyte. Therefore, it cannot be excluded that artificial oocyte activation could be of help in globozoospermic patients with complete fertilisation failure.
S Bechoua; A Chiron; S Delcleve-Paulhac; P Sagot; C Jimenez
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Andrologia     Volume:  41     ISSN:  1439-0272     ISO Abbreviation:  Andrologia     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-15     Completed Date:  2009-03-20     Revised Date:  2011-12-20    
Medline Journal Info:
Nlm Unique ID:  0423506     Medline TA:  Andrologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  55-8     Citation Subset:  IM    
Service de Biologie de la Reproduction, CECOS, CHU de Dijon, Maternité du Bocage, Dijon, France.
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MeSH Terms
Infertility, Male / therapy*
Oocytes / physiology
Pregnancy Outcome*
Sperm Injections, Intracytoplasmic*
Sperm-Ovum Interactions
Spermatozoa / abnormalities*

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