Document Detail

Fertilisation involving ageing gametes, major birth defects, and Down's syndrome.
MedLine Citation:
PMID:  12020531     Owner:  NLM     Status:  MEDLINE    
For many years, ageing of gametes as a result of prolonged retention in the female reproductive tract before fertilisation has been circumstantially associated with major birth defects. To assess this association, we studied pregnant women who had recorded the timing, with regard to presumed ovulation, of the coital event leading to conception. We found major anomalies in 11 (2.7%) of 400 infants born to women with optimally timed conceptions (on the day of or 1 day before ovulation), compared with 14 (2.5%) of 538 infants of women with non-optimally timed conceptions (odds ratio 0.94, 95% CI 0.43-2.06). The numbers of infants with Down's syndrome were two (0.5%) of 400, and four (0.7%) of 538, respectively (1.48, 0.27-8.06). There is no association between ageing gametes and major birth defects, including Down's syndrome.
Joe Leigh Simpson; Ron Gray; Alfredo Perez; Patricio Mena; John T Queenan; Michele Barbato; Francesco Pardo; Robert Kambic; Victoria Jennings
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Lancet     Volume:  359     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-21     Completed Date:  2002-06-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  1670-1     Citation Subset:  AIM; IM    
Baylor College of Medicine, Houston, TX 77030, USA.
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MeSH Terms
Abortion, Spontaneous / epidemiology
Cell Aging / physiology*
Chile / epidemiology
Colombia / epidemiology
Congenital Abnormalities / epidemiology*
District of Columbia / epidemiology
Down Syndrome / epidemiology*
Fertilization / physiology*
Germ Cells / physiology*
Infant, Newborn
Italy / epidemiology
Pregnancy Outcome
Time Factors

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