| Fertilisation involving ageing gametes, major birth defects, and Down's syndrome. | |
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MedLine Citation:
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PMID: 12020531 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For many years, ageing of gametes as a result of prolonged retention in the female reproductive tract before fertilisation has been circumstantially associated with major birth defects. To assess this association, we studied pregnant women who had recorded the timing, with regard to presumed ovulation, of the coital event leading to conception. We found major anomalies in 11 (2.7%) of 400 infants born to women with optimally timed conceptions (on the day of or 1 day before ovulation), compared with 14 (2.5%) of 538 infants of women with non-optimally timed conceptions (odds ratio 0.94, 95% CI 0.43-2.06). The numbers of infants with Down's syndrome were two (0.5%) of 400, and four (0.7%) of 538, respectively (1.48, 0.27-8.06). There is no association between ageing gametes and major birth defects, including Down's syndrome. |
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Authors:
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Joe Leigh Simpson; Ron Gray; Alfredo Perez; Patricio Mena; John T Queenan; Michele Barbato; Francesco Pardo; Robert Kambic; Victoria Jennings |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Lancet Volume: 359 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-21 Completed Date: 2002-06-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: England |
Other Details:
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Languages: eng Pagination: 1670-1 Citation Subset: AIM; IM |
Affiliation:
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Baylor College of Medicine, Houston, TX 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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epidemiology Adult Cell Aging / physiology* Chile / epidemiology Colombia / epidemiology Congenital Abnormalities / epidemiology* District of Columbia / epidemiology Down Syndrome / epidemiology* Female Fertilization / physiology* Germ Cells / physiology* Humans Infant, Newborn Italy / epidemiology Pregnancy Pregnancy Outcome Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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