Document Detail


Ferroxidases and xanthine oxidase in plasma of healthy newborn infants.
MedLine Citation:
PMID:  11767413     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the neonatal period, there is a high iron load, while both the level and molar oxidase activity of ceruloplasmin are low. On the other hand, the neonatal xanthine oxidase (XO) activity is higher than later in life and XO has a significant iron-oxidizing capacity. We therefore studied the physiological contribution of XO to the ferroxidase activity of the plasma in 20 full-term newborn infants. Ferroxidase activity was measured spectrophotometrically, with Fe++ as substrate. The uric acid formed by XO was assayed by means of HPLC, with electrochemical detection. The total ferroxidase activity in the plasma was about one-fourth of the adult level and rapidly increased doubling within 3 days after birth. About 90% of the plasma ferroxidase activity was due to ceruloplasmin, the remainder being accounted for by ferroxidase II. The XO activity underwent a 30% (statistically non-significant) elevation at 24 h, though ferroxidase activity attributable to XO was not detected at any time. Accordingly, XO does not seem to add substantially to the total iron-oxidizing capacity of the plasma in the neonatal period. The high molar ferroxidase activity is probably of importance at the endothelial cell surface.
Authors:
E Karg; H Orvos; A Papp; N Beck; S Turi; I Nemeth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Free radical research     Volume:  35     ISSN:  1071-5762     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-20     Completed Date:  2002-02-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  555-61     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Szeged, Albert Szent-Györgyi Medical School, H-6724 Szeged, Koranyi fasor 14-15, Hungary. karg@pedia.szote.u-szeged.hu
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Ceruloplasmin / analysis*
Humans
Infant, Newborn / blood*
Middle Aged
Oxidoreductases / blood
Reference Values
Xanthine Oxidase / blood*
Chemical
Reg. No./Substance:
EC 1.-/Oxidoreductases; EC 1.16.-/ferroxidase II; EC 1.16.3.1/Ceruloplasmin; EC 1.17.3.2/Xanthine Oxidase

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