| Ferrous chelator 2,2'-dipyridyl attenuates cerebral vasospasm after experimental subarachnoid haemorrhage in rabbits. | |
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MedLine Citation:
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PMID: 20515571 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of 2,2'-dipyridyl (DP) on cerebral vasospasm was investigated in a double-injection rabbit model of subarachnoid haemorrhage (SAH). Thirty-six animals were divided between four groups: control (sham-operated), SAH (model alone), SAH + DP (the SAH model in which DP dissolved in dimethyl sulphoxide [DMSO] was injected once daily for 5 days into the cisterna magna), and SAH + DMSO (the SAH model in which DMSO [vehicle] was injected daily for 5 days). There were significant differences in the basilar artery luminal area, wall thickness, neurological deficit score and vasospasm index between the SAH + DP and SAH groups. There was a significant negative correlation between arterial luminal area and arterial wall thickness, and also between the neurological deficit score and vasospasm index. Cells that were positive for terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labelling (TUNEL) and p53 expression were significantly increased in the SAH + DMSO and SAH groups, but not in the SAH + DP group, versus controls. Thus, DP may attenuate cerebral vasospasm after SAH by suppressing p53-induced apoptosis in the cerebral vessels. |
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Authors:
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Y Y Yu; L Niu; L Gao; G L Zhang; J Li; J P Deng; Y Z Qu; Z W Zhao; G D Gao |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of international medical research Volume: 38 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-06-02 Completed Date: 2010-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
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Languages: eng Pagination: 583-92 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2,2'-Dipyridyl
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pharmacology* Animals Apoptosis / drug effects Blotting, Western Chelating Agents / pharmacology* Disease Models, Animal* Immunoblotting Immunoenzyme Techniques Male Rabbits Subarachnoid Hemorrhage / drug therapy* Tumor Suppressor Protein p53 / metabolism Vasospasm, Intracranial / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 0/Tumor Suppressor Protein p53; 366-18-7/2,2'-Dipyridyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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