Document Detail

Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption.
MedLine Citation:
PMID:  18782341     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Alcohol consumption is associated with increased iron stores. In sub-Saharan Africa, high dietary ionic iron and the ferroportin Q248H allele have also been implicated in iron accumulation. We examined the associations of ferroportin Q248H, alcohol and dietary iron with serum ferritin, aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT) concentrations in African-Americans.
METHODS: Inner-city African-Americans (103 men, 40 women) were recruited from the community according to reported ingestion of >4 alcoholic drinks/d or <2/wk. Typical daily heme iron, nonheme iron and alcohol were estimated using University of Hawaii's multiethnic dietary questionnaire. Based on dietary questionnaire estimates we established categories of < versus > or =56 g alcohol/d, equivalent to 4 alcoholic drinks/d assuming 14 g alcohol per drink.
RESULTS: Among 143 participants, 77% drank <56 g alcohol/d and 23%> or =56 g/d as estimated by the questionnaire. The prevalence of ferroportin Q248H was 23.3% with alcohol >56 g/d versus 7.5% with lower amounts (p = 0.014). Among subjects with no history of HIV disease, serum ferritin concentration had positive relationships with male gender (p = 0.041), alcohol consumption (p = 0.021) and ALT concentration (p = 0.0001) but not with dietary iron intake or ferroportin Q248H. Serum AST and ALT concentrations had significant positive associations with male gender and hepatitis C seropositivity but not with alcohol or dietary iron intake or ferroportin Q248H.
CONCLUSIONS: Our findings suggest a higher prevalence of ferroportin Q248H with greater alcohol consumption, and this higher prevalence raises the possibility that the allele might ameliorate the toxicity of alcohol. Our results suggest that alcohol but not dietary iron contributes to higher body iron stores in African-Americans. Studies with larger numbers of participants are needed to further clarify the relationship of ferroportin Q248H with the toxicity of alcohol consumption.
Victor R Gordeuk; Sharmin F Diaz; Gladys O Onojobi; Ishmael Kasvosve; Zufan Debebe; Amanuel Edossa; Jeremy M Pantin; Shigang Xiong; Sergei Nekhai; Mehdi Nouraie; Hidekazu Tsukamoto; Robert E Taylor
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-09-06
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  32     ISSN:  1530-0277     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-02-09     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1947-53     Citation Subset:  IM    
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MeSH Terms
African Americans / genetics*
Alanine Transaminase / blood
Alcohol Drinking / ethnology,  genetics*,  metabolism*
Aspartate Aminotransferases / blood
Cation Transport Proteins / genetics*
Ferritins / blood*,  metabolism
Health Surveys
Hemeproteins / metabolism
Iron, Dietary / metabolism*
Middle Aged
Models, Statistical
Mutation / genetics
Regression Analysis
Urban Population
Grant Support
2 R25 HL003679-08/HL/NHLBI NIH HHS; 2M01 RR10284-10/RR/NCRR NIH HHS; P20 AA014643/AA/NIAAA NIH HHS; P20 AA014643-03/AA/NIAAA NIH HHS; P20 AA014643-03/AA/NIAAA NIH HHS; P50 AA11199/AA/NIAAA NIH HHS; SC1 GM082325/GM/NIGMS NIH HHS
Reg. No./Substance:
0/Cation Transport Proteins; 0/Hemeproteins; 0/Iron, Dietary; 0/haemoferritin; 0/metal transporting protein 1; 9007-73-2/Ferritins; EC Aminotransferases; EC Transaminase

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