Document Detail

Ferrocyanide ingestion may cause false positives in cyanide determination.
MedLine Citation:
PMID:  10384799     Owner:  NLM     Status:  MEDLINE    
The authors present a patient who ingested a cyanide containing solution and arrived at the hospital without any clinical evidence of intoxication but an elevated blood cyanide level. The authors explain this discrepancy with the following hypotheses: 1) the patient ingested cyanide as an iron-chelated complex; and 2) the sulfuric acid used in the standard microdiffusion technique released cyanide from its iron-bound state to result in the observed elevated blood cyanide. Through a series of in vitro analyses, the authors demonstrate the following: 1) the ingested solution tested positive for cyanide with the sulfuric acid technique and negative for cyanide with acetic acid; 2) the presence of a ferrous salt in the ingested product by a colorimetric redox titration technique; and 3) release of a small fraction of the total cyanide from ferrocyanide by the sulfuric acid technique. The authors conclude: 1) the patient ingested potassium ferrocyanide; and 2) the strong acid used in the cyanide microdiffusion assay will liberate cyanide that is chelated to iron to yield false positive results.
M Laforge; H Gourlain; D Fompeydie; F Buneaux; S W Borron; M Galliot-Guilley
Related Documents :
163659 - Hemoglobin j-chicago (beta76(e20) ala yields asp): a new hemoglobin variant resulting f...
12672409 - Measurement of protein and lipid hydroperoxides in biological systems by the ferric-xyl...
2766669 - Change in red blood cell distribution width with iron deficiency.
22061419 - Fatty acid composition and quality characteristics of low-fat cooked sausages made with...
22062859 - Relationships between dietary fatty acid composition and either melting point or fatty ...
12680669 - Microbial sulfate reduction at low ph in sediments of an acidic lake in argentina.
7445999 - Perinatal asphyxia in spite of a normal cardiotocogram and a normal acid base state at ...
3838089 - Comparison of intraluminal and intravenous mediators of colonic response to eating.
7447359 - Effect of platelets on apparent leucocyte ascorbic acid content.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  37     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  1999  
Date Detail:
Created Date:  1999-07-13     Completed Date:  1999-07-13     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  337-40     Citation Subset:  AIM; IM    
Hôpital Fernand Widal, Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cyanides / blood*,  poisoning,  toxicity
False Positive Reactions
Ferric Compounds / blood
Ferrocyanides / administration & dosage*,  blood,  pharmacokinetics
Ferrous Compounds / blood
Reg. No./Substance:
0/Cyanides; 0/Ferric Compounds; 0/Ferrocyanides; 0/Ferrous Compounds; 13408-63-4/hexacyanoferrate II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Acute, fatal, oral chromic acid poisoning.
Next Document:  Adolescent gynecology in the office setting.