Document Detail


Ferrocyanide ingestion may cause false positives in cyanide determination.
MedLine Citation:
PMID:  10384799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors present a patient who ingested a cyanide containing solution and arrived at the hospital without any clinical evidence of intoxication but an elevated blood cyanide level. The authors explain this discrepancy with the following hypotheses: 1) the patient ingested cyanide as an iron-chelated complex; and 2) the sulfuric acid used in the standard microdiffusion technique released cyanide from its iron-bound state to result in the observed elevated blood cyanide. Through a series of in vitro analyses, the authors demonstrate the following: 1) the ingested solution tested positive for cyanide with the sulfuric acid technique and negative for cyanide with acetic acid; 2) the presence of a ferrous salt in the ingested product by a colorimetric redox titration technique; and 3) release of a small fraction of the total cyanide from ferrocyanide by the sulfuric acid technique. The authors conclude: 1) the patient ingested potassium ferrocyanide; and 2) the strong acid used in the cyanide microdiffusion assay will liberate cyanide that is chelated to iron to yield false positive results.
Authors:
M Laforge; H Gourlain; D Fompeydie; F Buneaux; S W Borron; M Galliot-Guilley
Related Documents :
19493009 - 10-undecanhydroxamic acid, a hydroxamate derivative of the undecanoic acid, has strong ...
10384799 - Ferrocyanide ingestion may cause false positives in cyanide determination.
3040709 - Phytic acid. a natural antioxidant.
6972999 - Identification of leukemia-associated inhibitory activity as acidic isoferritins. a reg...
7738689 - Reduction of fe(iii) is required for uptake of nonheme iron by caco-2 cells.
22063429 - Carcass traits of rambouillet and merino × rambouillet lambs and fatty acid profiles o...
4829929 - Chemical and physical properties of lipopolysaccharide of yersinia pestis.
1769429 - Intragastric ph in the gastroprotective and ulcer-healing activity of aluminum-containi...
17343829 - Glucuronidation of fenamates: kinetic studies using human kidney cortical microsomes an...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  37     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  1999  
Date Detail:
Created Date:  1999-07-13     Completed Date:  1999-07-13     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  337-40     Citation Subset:  AIM; IM    
Affiliation:
Hôpital Fernand Widal, Paris, France. mlaforge@club-internet.fr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Colorimetry
Cyanides / blood*,  poisoning,  toxicity
False Positive Reactions
Ferric Compounds / blood
Ferrocyanides / administration & dosage*,  blood,  pharmacokinetics
Ferrous Compounds / blood
Humans
Male
Chemical
Reg. No./Substance:
0/Cyanides; 0/Ferric Compounds; 0/Ferrocyanides; 0/Ferrous Compounds; 13408-63-4/hexacyanoferrate II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Acute, fatal, oral chromic acid poisoning.
Next Document:  Adolescent gynecology in the office setting.