| Ferrocyanide ingestion may cause false positives in cyanide determination. | |
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MedLine Citation:
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PMID: 10384799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CASE REPORT: The authors present a patient who ingested a cyanide containing solution and arrived at the hospital without any clinical evidence of intoxication but an elevated blood cyanide level. The authors explain this discrepancy with the following hypotheses: 1) the patient ingested cyanide as an iron-chelated complex; and 2) the sulfuric acid used in the standard microdiffusion technique released cyanide from its iron-bound state to result in the observed elevated blood cyanide. Through a series of in vitro analyses, the authors demonstrate the following: 1) the ingested solution tested positive for cyanide with the sulfuric acid technique and negative for cyanide with acetic acid; 2) the presence of a ferrous salt in the ingested product by a colorimetric redox titration technique; and 3) release of a small fraction of the total cyanide from ferrocyanide by the sulfuric acid technique. The authors conclude: 1) the patient ingested potassium ferrocyanide; and 2) the strong acid used in the cyanide microdiffusion assay will liberate cyanide that is chelated to iron to yield false positive results. |
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Authors:
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M Laforge; H Gourlain; D Fompeydie; F Buneaux; S W Borron; M Galliot-Guilley |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of toxicology. Clinical toxicology Volume: 37 ISSN: 0731-3810 ISO Abbreviation: J. Toxicol. Clin. Toxicol. Publication Date: 1999 |
Date Detail:
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Created Date: 1999-07-13 Completed Date: 1999-07-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8213460 Medline TA: J Toxicol Clin Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 337-40 Citation Subset: AIM; IM |
Affiliation:
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Hôpital Fernand Widal, Paris, France. mlaforge@club-internet.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Colorimetry Cyanides / blood*, poisoning, toxicity False Positive Reactions Ferric Compounds / blood Ferrocyanides / administration & dosage*, blood, pharmacokinetics Ferrous Compounds / blood Humans Male |
| Chemical | |
Reg. No./Substance:
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0/Cyanides; 0/Ferric Compounds; 0/Ferrocyanides; 0/Ferrous Compounds; 13408-63-4/hexacyanoferrate II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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