Document Detail


Ferrocyanide ingestion may cause false positives in cyanide determination.
MedLine Citation:
PMID:  10384799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors present a patient who ingested a cyanide containing solution and arrived at the hospital without any clinical evidence of intoxication but an elevated blood cyanide level. The authors explain this discrepancy with the following hypotheses: 1) the patient ingested cyanide as an iron-chelated complex; and 2) the sulfuric acid used in the standard microdiffusion technique released cyanide from its iron-bound state to result in the observed elevated blood cyanide. Through a series of in vitro analyses, the authors demonstrate the following: 1) the ingested solution tested positive for cyanide with the sulfuric acid technique and negative for cyanide with acetic acid; 2) the presence of a ferrous salt in the ingested product by a colorimetric redox titration technique; and 3) release of a small fraction of the total cyanide from ferrocyanide by the sulfuric acid technique. The authors conclude: 1) the patient ingested potassium ferrocyanide; and 2) the strong acid used in the cyanide microdiffusion assay will liberate cyanide that is chelated to iron to yield false positive results.
Authors:
M Laforge; H Gourlain; D Fompeydie; F Buneaux; S W Borron; M Galliot-Guilley
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  37     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  1999  
Date Detail:
Created Date:  1999-07-13     Completed Date:  1999-07-13     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  337-40     Citation Subset:  AIM; IM    
Affiliation:
Hôpital Fernand Widal, Paris, France. mlaforge@club-internet.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Colorimetry
Cyanides / blood*,  poisoning,  toxicity
False Positive Reactions
Ferric Compounds / blood
Ferrocyanides / administration & dosage*,  blood,  pharmacokinetics
Ferrous Compounds / blood
Humans
Male
Chemical
Reg. No./Substance:
0/Cyanides; 0/Ferric Compounds; 0/Ferrocyanides; 0/Ferrous Compounds; 13408-63-4/hexacyanoferrate II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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