| Ferric reducing, antiradical and beta-carotene bleaching activities of nicotinic acid and picolinic acid bioconjugates of curcumin. | |
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MedLine Citation:
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PMID: 22312728 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Although curcumin displays several beneficial properties, its medicinal use is limited by its low bioavailability. In the present study we report the antioxidant potentials of two bioconjugates of curcumin with nicotinic acid and picolinic acid: di-O-nicotinoyl curcumin [1,7-bis (4-O nicotinoyl-3-methoxyphenyl)-1,6-heptadiene-3, 5-dione] and di-O-picolinoyl curcumin [1,7-bis (4-O-picolinoyl-3-methoxyphenyl)-1,6-heptadiene-3, 5-dione], in terms of ferric reducing, radical scavenging and beta-carotene bleaching abilities, and comparing the observed activity with that of curcumin. Results demonstrate that both the bioconjugates possess higher antioxidant potentials as evidenced by enhanced ferric reducing, radical scavenging and beta-carotene bleaching abilities, in comparison with curcumin. On the basis of our results we conclude that these bioconjugates of curcumin may be better than curcumin for medicinal and pharmacological applications. |
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Authors:
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Archana Pandey; Kanti Bhooshan Pandey; Ravindra Kumar Gupta; Syed Ibrahim Rizvi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Natural product communications Volume: 6 ISSN: 1934-578X ISO Abbreviation: Nat Prod Commun Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-02-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101477873 Medline TA: Nat Prod Commun Country: United States |
Other Details:
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Languages: eng Pagination: 1877-80 Citation Subset: IM |
Affiliation:
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Department of Chemistry, C.MP College, Allahabad, Allahabad-211002, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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