Document Detail


Ferric reducing, antiradical and beta-carotene bleaching activities of nicotinic acid and picolinic acid bioconjugates of curcumin.
MedLine Citation:
PMID:  22312728     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Although curcumin displays several beneficial properties, its medicinal use is limited by its low bioavailability. In the present study we report the antioxidant potentials of two bioconjugates of curcumin with nicotinic acid and picolinic acid: di-O-nicotinoyl curcumin [1,7-bis (4-O nicotinoyl-3-methoxyphenyl)-1,6-heptadiene-3, 5-dione] and di-O-picolinoyl curcumin [1,7-bis (4-O-picolinoyl-3-methoxyphenyl)-1,6-heptadiene-3, 5-dione], in terms of ferric reducing, radical scavenging and beta-carotene bleaching abilities, and comparing the observed activity with that of curcumin. Results demonstrate that both the bioconjugates possess higher antioxidant potentials as evidenced by enhanced ferric reducing, radical scavenging and beta-carotene bleaching abilities, in comparison with curcumin. On the basis of our results we conclude that these bioconjugates of curcumin may be better than curcumin for medicinal and pharmacological applications.
Authors:
Archana Pandey; Kanti Bhooshan Pandey; Ravindra Kumar Gupta; Syed Ibrahim Rizvi
Related Documents :
24161508 - Aspartic acid incorporated monolithic columns for affinity glycoprotein purification.
10893518 - Temporal changes of cerebral metabolites and striatal lesions in acute 3-nitropropionic...
15747118 - Kinetics of bifidobacterium longum atcc 15707 fermentations: effect of the dilution rat...
23281168 - Influence of different amino acid groups on the free radical scavenging capability of m...
12534408 - Effective intra-oesophageal acid suppression in patients with gastro-oesophageal reflux...
4572708 - Isoleucine and valine metabolism in escherichia coli. xxi. mutations affecting derepres...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Natural product communications     Volume:  6     ISSN:  1934-578X     ISO Abbreviation:  Nat Prod Commun     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-02-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101477873     Medline TA:  Nat Prod Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1877-80     Citation Subset:  IM    
Affiliation:
Department of Chemistry, C.MP College, Allahabad, Allahabad-211002, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  HPLC/PDA/ESI-MS evaluation of saffron (Crocus sativus L.) adulteration.
Next Document:  Antiviral activities of diarylheptanoids isolated from Alpinia officinarum against respiratory syncy...