| Fermentation potential of the gut microbiome: implications for energy homeostasis and weight management. | |
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MedLine Citation:
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PMID: 21294743 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Energy homeostasis is regulated by twin factors, energy intake and energy expenditure. Obesity arises when these two factors are out of balance. Recently, the microflora residing in the human gut has been found to be one of the influential factors disturbing energy balance. Recent interest in this field has led to use of the term "gut microbiome" to describe the genomes of trillions of microbes residing in the gut. Metagenomic studies have shown that the human gut microbiome facilitates fermentation of indigestible carbohydrates to short-chain fatty acids that provide excess energy to the body, thus contributing to the obese phenotype. Alteration in the ratio of Bacteroidetes and Firmicutes drives a change in fermentation patterns that could explain weight gain. Therefore, changes in the gut microbiome (induced by antibiotics or dietary supplements) may be helpful in curbing the obesity pandemic. This review provides information on the expansive role the gut microbiome is believed to play in obesity and other related metabolic disorders. |
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Authors:
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Tulika Arora; Rajkumar Sharma |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutrition reviews Volume: 69 ISSN: 1753-4887 ISO Abbreviation: Nutr. Rev. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376405 Medline TA: Nutr Rev Country: United States |
Other Details:
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Languages: eng Pagination: 99-106 Citation Subset: IM |
Copyright Information:
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© 2011 International Life Sciences Institute. |
Affiliation:
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Animal Biochemistry Division, National Dairy Research Institute, Karnal 135001, Haryana, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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