Document Detail

Fermentation of dietary starch in humans.
MedLine Citation:
PMID:  10763953     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Dietary starch that escapes digestion in the small intestine may be quantitatively more important than dietary fiber as a substrate for fermentation. The products of fermentation have important implications in the pathogenesis of colorectal cancer and other diseases of the large bowel, which are uncommon in Africans but have a high prevalence in Western populations. METHODS: Maize porridge is a staple of most blacks in South Africa. Stale maize porridge (high-resistant starch [HRS]) seems to induce greater fermentation in the large bowel than fresh maize porridge (low-resistant starch [LRS]). RESULTS: In the present study, healthy colostomy subjects fed stale maize porridge had significantly more production of short-chain fatty acids (SCFA) (mean SCFA, HRS = 182.6; mean SCFA, LRS = 116.1; p < 0.05) in their colostomy effluent together with a significant drop in stool pH (mean pH, HRS = 5.91; mean pH, LRS = 6.70; p < 0.001). The SCFA butyrate (mean, HRS = 35.1; mean, LRS = 17.6; p < 0.05) and acetate (mean, HRS = 93.9; mean, LRS = 65.8; p < 0.05) were significantly elevated on the stale maize porridge diet when compared with consumption of fresh maize porridge. SCFA propionate (mean, HRS = 43.1; mean, LRS = 24.8; p = 0.05), also increased with stale maize porridge, but was not statistically significant. CONCLUSION: A high-resistant starch diet and its resultant increase in fermentation products may be partly responsible for protecting the black population against colorectal cancers and other large bowel diseases.
R Ahmed; I Segal; H Hassan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  95     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-04-25     Completed Date:  2000-04-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1017-20     Citation Subset:  IM    
Gastroenterology Division, Chris Hani Baragwanath Hospital, Soweto, South Africa.
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MeSH Terms
Acetic Acid / metabolism
African Continental Ancestry Group*
Butyrates / metabolism
Colorectal Neoplasms / prevention & control
Dietary Carbohydrates / metabolism*
Fatty Acids, Volatile / metabolism
Gastrointestinal Transit / physiology
Hydrogen-Ion Concentration
Intestines / metabolism
Risk Factors
South Africa
Zea mays / metabolism*
Reg. No./Substance:
0/Butyrates; 0/Dietary Carbohydrates; 0/Fatty Acids, Volatile; 64-19-7/Acetic Acid

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