| Ferilnic nirate produces delayed preconditioning against myocardial ischemia and reperfusion injury in rats. | |
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MedLine Citation:
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PMID: 20607493 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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To determine whether ferilnic nirate (FLNT) can precondition the rat heart against myocardial ischemia/reperfusion (I/R) damage and its mechanism, two groups of experiments were conducted. In the first group of experiments, rats were divided among four treatment groups: sham group; solvent with I/R (I/R control group); FLNT pretreatment with I/R (I/R FLNT group); and late ischemic preconditioning group (LPC group). In the second group of experiments without I/R, rats were divided into two treatment groups: control group and FLNT group. The results indicated that myocardial infarct size and the levels of creatine kinase and lactate dehydrogenase in the sera of the I/R FLNT group were significantly lower and the level of nitric oxide molecule and Mn-containing superoxide dismutase were significantly elevated in the heart tissue compared with I/R control group. The protein expression ratio of Bcl-2/Bax in heart tissue was significantly elevated in the I/R FLNT group. These results demonstrate FLNT is able to precondition rat hearts against myocardial ischemia/reperfusion damage to a similar level as that achieved via the late phase of ischemic preconditioning. The mechanism may involve the up-regulation of nitric oxide and the strengthening of anti-oxidant and anti-apoptosis cellular functions. |
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Authors:
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Jing-feng Xu; Zhan-qing Wang; Jin-ping Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-06 |
Journal Detail:
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Title: Archives of pharmacal research Volume: 33 ISSN: 0253-6269 ISO Abbreviation: Arch. Pharm. Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000036 Medline TA: Arch Pharm Res Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 881-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, General Hospital of Beijing Military Command, Beijing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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