| Fenvalerate exposure alters thyroid hormone status in selenium- and/or iodine-deficient rats. | |
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MedLine Citation:
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PMID: 19727571 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Considering the potential adverse effects of selenium and iodine deficiencies, and taking into account the widespread but often careless use of pyrethroid insecticides and their possible endocrine-disrupting effects, this study was undertaken to investigate the effects of fenvalerate on thyroid hormone parameters in both healthy and selenium- and/or iodine-deficient rats. Fenvalerate exposure had no effect on the TT4 levels of healthy controls but caused significant increases both in iodine deficiency (ID) and selenium plus iodine deficiency (ISeD), and a significant decrease in selenium deficiency (SeD). Dramatic increases in TT3 of all groups were observed by fenvalerate. Moreover, it caused insignificant decrease of thyroid stimulating hormone in healthy controls, no effect in SeD, and significant elevation in ID and ISeD. These results, thus, showed that the widely used pyrethroid insecticide fenvalerate has the potential to change significantly thyroid hormone parameters both in normal and deficiency states, and consequences of its thyroid status modifying effect might be of critical importance particularly in sensitive individuals and patients with thyroid dysfunction. |
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Authors:
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Belma Giray; Aydan Cağlayan; Pinar Erkekoğlu; Filiz Hincal |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-02 |
Journal Detail:
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Title: Biological trace element research Volume: 135 ISSN: 1559-0720 ISO Abbreviation: Biol Trace Elem Res Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-08-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: United States |
Other Details:
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Languages: eng Pagination: 233-41 Citation Subset: IM |
Affiliation:
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Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara 06100, Turkey. bgiray@hacettepe.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Iodine / deficiency* Male Nitriles / adverse effects* Pyrethrins / adverse effects* Rats Rats, Wistar Selenium / deficiency* Thyroid Gland / anatomy & histology, drug effects* Thyroid Hormones / metabolism* Thyrotropin / metabolism Thyroxine / metabolism Triiodothyronine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Nitriles; 0/Pyrethrins; 0/Thyroid Hormones; 51630-58-1/fenvalerate; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 7553-56-2/Iodine; 7782-49-2/Selenium; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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