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Fenton-like degradation of nalidixic acid with Fe(3+)/H (2)O (2).
MedLine Citation:
PMID:  23128991     Owner:  NLM     Status:  Publisher    
The Fenton-like degradation of nalidixic acid was studied in this work. The effects of Fe(3+) concentration and initial H(2)O(2) concentration were investigated. Increasing the initial H(2)O(2) concentration enhances the degradation and mineralization efficiency for nalidixic acid, while Fe(3+) shows an optimal concentration of 0.25 mM. A complete removal of nalidixic acid and a TOC removal of 28 % were achieved in 60 min under a reaction condition of [Fe(3+)] = 0.25 mM, [H(2)O(2)] = 10 mM, T = 35 °C, and pH = 3. LC-MS analysis technique was used to analyze the possible degradation intermediates. The degradation pathways of nalidixic acid were proposed according to the identified intermediates and the electron density distribution of nalidixic acid. The Fenton-like degradation reaction of nalidixic acid mainly begins with the electrophilic attack of hydroxyl radical towards the C(3) position which results in the ring-opening reaction; meanwhile, hydroxyl radical attacking to the branched alkyl groups of nalidixic acid leads to the oxidation at the branched alkyl groups.
Xiangqun Fan; Hongyuan Hao; Yongchuan Wang; Feng Chen; Jinlong Zhang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-6
Journal Detail:
Title:  Environmental science and pollution research international     Volume:  -     ISSN:  1614-7499     ISO Abbreviation:  Environ Sci Pollut Res Int     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441769     Medline TA:  Environ Sci Pollut Res Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, 200237, People's Republic of China,
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