| Fentanyl reduces infarction but not stunning via delta-opioid receptors and protein kinase C in rats. | |
| | |
MedLine Citation:
|
PMID: 10844838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Langendorff rat hearts were used (i) to examine whether fentanyl reduces stunning, infarction or both, and (ii) to investigate if this protection is mediated by delta-opioid receptors and/or protein kinase C (PKC). In the stunning study, hearts were subjected to global ischaemia (20 min) and reperfusion. This did not produce infarction. Postischaemic mechanical function was measured in hearts treated with or without fentanyl (740 nM). Fentanyl did not affect postischaemic mechanical function. In the infarction study, the left anterior descending coronary artery was occluded for 35 min and infarct size was assessed by triphenyltetrazolium chloride staining. Hearts in the control group exhibited an infarct zone/area at risk (I/R) of 39 (SEM 5)%, whereas the I/R for the fentanyl group was 13 (2)%. When the hearts were treated with a delta-opioid receptor antagonist (naltrindole 1 nM) or a PKC inhibitor (chelerythrine 2 microM), the effect of fentanyl was abolished, with I/R of 37 (1) and 36 (2)% respectively. In our model, we conclude that fentanyl protects against infarction but not against stunning, and that the limitation of ischaemic injury is mediated by both delta-opioid receptors and PKC. |
| | |
Authors:
|
R Kato; P Foëx |
Related Documents
:
|
7930208 - Does ischemic preconditioning occur in patients? 8846418 - Bradykinin as an endogenous myocardial protective substance with particular reference t... 9196858 - Cardioprotection induced by ischemic preconditioning in the mammalian heart: effects on... 18706228 - Nitric oxide induces heat shock protein 72 production and delayed protection against my... 3144298 - Intracardiac thrombosis, phospholipid antibodies, and two-chambered right ventricle. 21785808 - Consensus document: antithrombotic therapy in patients with atrial fibrillation undergo... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: British journal of anaesthesia Volume: 84 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 2000 May |
Date Detail:
|
Created Date: 2000-06-14 Completed Date: 2000-06-14 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 608-14 Citation Subset: IM |
Affiliation:
|
Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analgesics, Opioid
/
therapeutic use* Animals Coloring Agents / diagnostic use Fentanyl / therapeutic use* Male Myocardial Infarction / drug therapy*, prevention & control Myocardial Stunning / drug therapy, prevention & control Protein Kinase C / antagonists & inhibitors, drug effects* Rats Rats, Wistar Receptors, Opioid, delta / antagonists & inhibitors, drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Analgesics, Opioid; 0/Coloring Agents; 0/Receptors, Opioid, delta; 437-38-7/Fentanyl; EC 2.7.11.13/Protein Kinase C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of exogenous surfactant and positive end-expiratory pressure therapies in a model of huma...
Next Document: Reduced cerebral embolic signals in beating heart coronary surgery detected by transcranial Doppler ...