Document Detail

Fenoprofen-induced immune hemolysis. Difficulties in diagnosis and complications in compatibility testing.
MedLine Citation:
PMID:  3348176     Owner:  NLM     Status:  MEDLINE    
A 70-year-old man developed severe immune intravascular hemolysis and renal failure following ingestion of fenoprofen, a nonsteroidal, anti-inflammatory drug. The patient's red blood cells were sensitized with both IgG and C3d. The serum reacted with normal red blood cells in the presence and absence of the drug. Addition of albumin to the serum inhibited the reactivity with both neat and drug-treated serum. These atypical serologic findings for drug-related immune hemolytic anemia were explained by (1) the measurement of fenoprofen by high performance liquid chromatography (HPLC) in the neat serum; and (2) solid-phase adsorption studies showing that albumin can bind drug, leading to the disappearance of agglutination when albumin is added. This case demonstrates the utility of drug levels and adsorption techniques to confirm the diagnosis of drug-induced immune hemolytic anemia despite the anomalous serologic results which obscured the diagnosis and management of the patient.
R S Shirey; S J Morton; K B Lawton; C Lowell; T S Kickler; P M Ness
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  89     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-04-11     Completed Date:  1988-04-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  410-4     Citation Subset:  AIM; IM    
Department of Laboratory Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21205.
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MeSH Terms
Anemia, Hemolytic, Autoimmune / chemically induced*,  complications,  diagnosis
Antigen-Antibody Reactions
Chromatography, High Pressure Liquid
Fenoprofen / adverse effects*
Histocompatibility Testing*
Phenylpropionates / adverse effects*
Reg. No./Substance:
0/Phenylpropionates; 31879-05-7/Fenoprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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