| Fenoprofen-induced immune hemolysis. Difficulties in diagnosis and complications in compatibility testing. | |
| | |
MedLine Citation:
|
PMID: 3348176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A 70-year-old man developed severe immune intravascular hemolysis and renal failure following ingestion of fenoprofen, a nonsteroidal, anti-inflammatory drug. The patient's red blood cells were sensitized with both IgG and C3d. The serum reacted with normal red blood cells in the presence and absence of the drug. Addition of albumin to the serum inhibited the reactivity with both neat and drug-treated serum. These atypical serologic findings for drug-related immune hemolytic anemia were explained by (1) the measurement of fenoprofen by high performance liquid chromatography (HPLC) in the neat serum; and (2) solid-phase adsorption studies showing that albumin can bind drug, leading to the disappearance of agglutination when albumin is added. This case demonstrates the utility of drug levels and adsorption techniques to confirm the diagnosis of drug-induced immune hemolytic anemia despite the anomalous serologic results which obscured the diagnosis and management of the patient. |
| | |
Authors:
|
R S Shirey; S J Morton; K B Lawton; C Lowell; T S Kickler; P M Ness |
Related Documents
:
|
11678006 - Comparison of ofloxacin and norfloxacin concentration in prostatic tissues in patients ... 2985676 - Pharmacokinetic interactions between digoxin and other drugs. 1486 - The in vitro adsorption of drugs from horse serum onto carbon coated with an acrylic hy... 7733456 - Interference of sodium azide with the quantitation of bilirubin: modification of fog's ... 18471776 - Effect of single-dose ivermectin on onchocerca volvulus: a systematic review and meta-a... 15619136 - Postmarketing surveillance of potentially fatal reactions to oncology drugs: potential ... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: American journal of clinical pathology Volume: 89 ISSN: 0002-9173 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 1988 Mar |
Date Detail:
|
Created Date: 1988-04-11 Completed Date: 1988-04-11 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 410-4 Citation Subset: AIM; IM |
Affiliation:
|
Department of Laboratory Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21205. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Anemia, Hemolytic, Autoimmune / chemically induced*, complications, diagnosis Antigen-Antibody Reactions Chromatography, High Pressure Liquid Fenoprofen / adverse effects* Histocompatibility Testing* Humans Male Phenylpropionates / adverse effects* |
| Chemical | |
Reg. No./Substance:
|
0/Phenylpropionates; 31879-05-7/Fenoprofen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Predictive value of an enzyme-linked immunosorbent assay (ELISA) for the serodiagnosis of strongyloi...
Next Document: Sexual precocity in girls. An association with sexual abuse?