| Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats. | |
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MedLine Citation:
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PMID: 11226439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fibrates are hypolipidemic drugs that activate the peroxisome proliferator-activated receptors. Since fibrates may also increase energy expenditure, we investigated whether fenofibrate (FF) had this effect in diet-induced obese rats. A 2-month administration of a high-fat palatable diet to adult rats increased body weight by 25% and white adipose mass by 163% compared with a standard diet. These effects were prevented by FF, both when administered for the 2 months of high-fat feeding and when given for only the second month. Consequently, FF-treated rats had a final body weight and white adipose tissue mass similar to untreated animals on the standard diet. FF also increased resting metabolic rate, hepatic peroxisomal and mitochondrial palmitoyl-dependent oxygen uptake and mRNA levels of acyl-CoA oxidase and lipoprotein lipase. Finally, FF lowered mRNA levels of uncoupling protein-2 and did not affect mitochondrial respiration in skeletal muscle. Therefore, FF seems to act as a weight-stabilizer mainly through its effect on liver metabolism. |
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Authors:
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F P Mancini; A Lanni; L Sabatino; M Moreno; A Giannino; F Contaldo; V Colantuoni; F Goglia |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 491 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-06 Completed Date: 2001-04-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 154-8 Citation Subset: IM |
Affiliation:
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Facoltá di Scienze Matematiche, Fisiche e Naturali, Universitá del Sannio, Via Port'Arsa 11, 82100 Benevento, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism* Animals Antilipemic Agents / pharmacology* Diet / adverse effects Energy Metabolism Glyceraldehyde-3-Phosphate Dehydrogenases / pharmacology Liver / metabolism, ultrastructure Male Mitochondria / metabolism Muscles / metabolism, ultrastructure Obesity / drug therapy*, metabolism Oxygen Consumption Peroxisomes / metabolism Procetofen / pharmacology* RNA, Messenger / metabolism Rats Rats, Wistar Receptors, Cytoplasmic and Nuclear / genetics, metabolism Reverse Transcriptase Polymerase Chain Reaction Transcription Factors / genetics, metabolism Uncoupling Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/RNA, Messenger; 0/Receptors, Cytoplasmic and Nuclear; 0/Transcription Factors; 0/Uncoupling Agents; 49562-28-9/Procetofen; EC 1.2.1.-/Glyceraldehyde-3-Phosphate Dehydrogenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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