| Fenofibrate, a peroxisome proliferator-activated receptor α agonist, alters triglyceride metabolism in enterocytes of mice. | |
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MedLine Citation:
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PMID: 21215818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fenofibrate, a drug in the fibrate class of amphiphathic carboxylic acids, has multiple blood lipid modifying actions, which are beneficial to the prevention of atherosclerosis. One of its benefits is in lowering fasting and postprandial blood triglyceride (TG) concentrations. The goal of this study was to determine whether the hypotriglyceridemic actions of fenofibrate in the postprandial state include alterations in TG and fatty acid metabolism in the small intestine. We found that the hypotriglyceridemic actions of fenofibrate in the postprandial state of high-fat (HF) fed mice include a decrease in supply of TG for secretion by the small intestine. A decreased supply of TG for secretion was due in part to the decreased dietary fat absorption and increased intestinal fatty acid oxidation in fenofibrate compared to vehicle treated HF fed mice. These results suggest that the effects of fenofibrate on the small intestine play a critical role in the hypotriglyceridemic effects of fenofibrate. |
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Authors:
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Aki Uchida; Mikhail N Slipchenko; Ji-Xin Cheng; Kimberly K Buhman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-01-06 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1811 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-04 Completed Date: 2011-03-29 Revised Date: 2012-09-24 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 170-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atherosclerosis / metabolism, prevention & control Dietary Fats / administration & dosage Enterocytes / metabolism* Fenofibrate / pharmacokinetics* Humans Hypolipidemic Agents / pharmacology* Intestinal Absorption / drug effects Intestine, Small / metabolism* Male Mice PPAR alpha / agonists* Postprandial Period / drug effects Triglycerides / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 EB007243-03/EB/NIBIB NIH HHS; R01EB7243/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Hypolipidemic Agents; 0/PPAR alpha; 0/Triglycerides; 49562-28-9/Fenofibrate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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