Document Detail


Fenofibrate, a peroxisome proliferator-activated receptor α agonist, alters triglyceride metabolism in enterocytes of mice.
MedLine Citation:
PMID:  21215818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fenofibrate, a drug in the fibrate class of amphiphathic carboxylic acids, has multiple blood lipid modifying actions, which are beneficial to the prevention of atherosclerosis. One of its benefits is in lowering fasting and postprandial blood triglyceride (TG) concentrations. The goal of this study was to determine whether the hypotriglyceridemic actions of fenofibrate in the postprandial state include alterations in TG and fatty acid metabolism in the small intestine. We found that the hypotriglyceridemic actions of fenofibrate in the postprandial state of high-fat (HF) fed mice include a decrease in supply of TG for secretion by the small intestine. A decreased supply of TG for secretion was due in part to the decreased dietary fat absorption and increased intestinal fatty acid oxidation in fenofibrate compared to vehicle treated HF fed mice. These results suggest that the effects of fenofibrate on the small intestine play a critical role in the hypotriglyceridemic effects of fenofibrate.
Authors:
Aki Uchida; Mikhail N Slipchenko; Ji-Xin Cheng; Kimberly K Buhman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-01-06
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1811     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-04     Completed Date:  2011-03-29     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  170-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atherosclerosis / metabolism,  prevention & control
Dietary Fats / administration & dosage
Enterocytes / metabolism*
Fenofibrate / pharmacokinetics*
Humans
Hypolipidemic Agents / pharmacology*
Intestinal Absorption / drug effects
Intestine, Small / metabolism*
Male
Mice
PPAR alpha / agonists*
Postprandial Period / drug effects
Triglycerides / metabolism*
Grant Support
ID/Acronym/Agency:
R01 EB007243/EB/NIBIB NIH HHS; R01 EB007243-03/EB/NIBIB NIH HHS; R01EB7243/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Hypolipidemic Agents; 0/PPAR alpha; 0/Triglycerides; 49562-28-9/Fenofibrate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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