| Fenofibrate Reduces Age-related Hypercholesterolemia in Normal Rats on a Standard Diet. | |
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MedLine Citation:
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PMID: 20473378 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Plasma cholesterol is increased in normal aging in both rodents and humans. This is associated with reduced elimination of cholesterol and decreased receptor-mediated clearance of plasma low-density lipoprotein (LDL) cholesterol. The aims of this study were: (1) to determine age-related changes in plasma lipid profiles, and (2) to determine the effect of fenofibrate, an activator of peroxisome proliferator activated receptor alpha (PPAR alpha), on plasma lipid profiles in normal rats on a standard diet. Male Sprague-Dawley (SD) rats (n=15) were fed standard chow and water from 10 to 25 weeks of age. During that period, we measured daily food intake, body weight, fasting and random blood glucose levels, plasma total cholesterol (TC), triglycerides (TG), and free fatty acid (FFA) levels. At 20 weeks of age, all rats were randomly divided into two groups: a fenofibrate group (in which rats were gavaged with 300 mg/kg/day of fenofibrate) and a control group (gavaged with water). Fenofibrate treatment lasted 5 weeks. There were no significant changes in daily food intake, blood glucose, and plasma TG level with age. Body weight, plasma TC, and FFA levels were significantly increased with age. Fenofibrate significantly decreased plasma concentrations of TC and FFA, which had been increased with age. However, fenofibrate did not influence the plasma concentration of TG, which had not increased with age. These results suggest that fenofibrate might have a novel role in preventing age-related hypercholesterolemia in SD rats on a normal diet. |
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Authors:
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Ying Han; Mi-Hyang Do; Mi Sun Kim; Eunhui Seo; Mi-Kyoung Park; Duk Kyu Kim; Hye-Jeong Lee; Su-Yeong Seo |
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Publication Detail:
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Type: Journal Article Date: 2010-04-30 |
Journal Detail:
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Title: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology Volume: 14 ISSN: 1226-4512 ISO Abbreviation: Korean J. Physiol. Pharmacol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709505 Medline TA: Korean J Physiol Pharmacol Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 77-81 Citation Subset: - |
Affiliation:
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Department of Pharmacology, Dong-A University College of Medicine, Medical Science Research Center, Busan 602-714, Korea. |
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