Document Detail


Fenitrothion, an organophosphate, affects running endurance but not aerobic capacity in fat-tailed dunnarts (Sminthopsis crassicaudata).
MedLine Citation:
PMID:  18547601     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We measured aerobic metabolism during cold exposure and exercise performance (run duration and oxygen consumption while running at 1 m s(-1)) in the fat-tailed dunnart Sminthopsis crassicaudata, a dasyurid marsupial, before and after ingestion of 30 mg kg(-1) of fenitrothion, an organophosphate (OP) pesticide. Running endurance of OP-exposed animals was less than half that of control animals over the first 3 days after dosing and 55% of control animal endurance on day 5 post-dose. Despite these declines, peak metabolic rate at this running speed (9.3 times basal metabolic rate; BMR) was unaffected by OP exposure. Peak metabolic rate (PMR) and cumulative oxygen consumption during a 1-h exposure to conditions equivalent to -20 degrees C did not differ between OP-treated and control dunnarts, with PMR averaging 11 times BMR. We conclude that fenitrothion-induced exercise fatigue is not due to limitations in oxygen or substrate delivery to muscle or in their uptake per se, but more likely relates to decreased ability to sustain high-frequency neuromuscular function. The persistence of locomotor impairment following OP exposure in otherwise asymptomatic animals emphasizes the importance of using performance-based measures when characterising sublethal effects of pesticide exposure in an ecological context.
Authors:
William A Buttemer; Paul G Story; Karen J Fildes; Russell V Baudinette; Lee B Astheimer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-10
Journal Detail:
Title:  Chemosphere     Volume:  72     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-08     Completed Date:  2008-10-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  1315-20     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences and The Institute for Conservation Biology, University of Wollongong, Wollongong, NSW, Australia. buttemer@uow.edu.au
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MeSH Terms
Descriptor/Qualifier:
Aerobiosis / drug effects*
Animals
Body Temperature Regulation / drug effects
Brain / drug effects,  enzymology
Cholinesterase Inhibitors / blood,  toxicity*
Cholinesterases / blood
Data Interpretation, Statistical
Fenitrothion / blood,  toxicity*
Insecticides / blood,  toxicity*
Male
Marsupialia / physiology*
Metabolism / drug effects
Pesticide Residues / blood
Physical Endurance / drug effects*
Running / physiology
Thermogenesis / drug effects
Chemical
Reg. No./Substance:
0/Cholinesterase Inhibitors; 0/Insecticides; 0/Pesticide Residues; 122-14-5/Fenitrothion; EC 3.1.1.8/Cholinesterases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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