Document Detail

Fenfluramine stimulation of prolactin in obsessive-compulsive disorder.
MedLine Citation:
PMID:  1603884     Owner:  NLM     Status:  MEDLINE    
The success of serotonergic reuptake inhibitors in the treatment of obsessive-compulsive disorder (OCD) has suggested that serotonergic neurotransmission may play a role in the pathogenisis of this disorder. Prolactin responses to a 60-mg oral dose of fenfluramine in 26 medication-free patients with a DSM-III-R diagnosis of OCD were compared with those of 20 controls subjects. Fenfluramine produced a significant elevation of prolactin levels in both OCD patients and controls. Prolactin responses were significantly blunted in OCD patients compared with responses in control subjects. Female subjects in both groups showed greater prolactin responses to fenfluramine than did their male counterparts. There was a significant interaction between sex and the presence of OCD such that female patients had lower prolactin responses than their controls, while the difference between male patients and controls was not significant. Prolactin responses were not correlated with age, weight, drug level, depression, anxiety, or degree of OCD symptoms. The results are consistent with a relative reduction in serotonergic efficacy in the setting of OCD.
W A Hewlett; S Vinogradov; K Martin; S Berman; J G Csernansky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychiatry research     Volume:  42     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-07-13     Completed Date:  1992-07-13     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  81-92     Citation Subset:  IM    
Vanderbilt University School of Medicine, Nashville, TN.
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MeSH Terms
Fenfluramine / diagnostic use*
Middle Aged
Obsessive-Compulsive Disorder / blood,  diagnosis*,  psychology
Prolactin / blood*
Sex Factors
Reg. No./Substance:
458-24-2/Fenfluramine; 9002-62-4/Prolactin

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