Document Detail

Fenfluramine challenge test as a marker of serotonin activity in patients with Alzheimer's dementia and agitation.
MedLine Citation:
PMID:  9807649     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Changes in serotonin (5-HT) have been described in both Alzheimer's disease (AD) and aggressive/agitated behaviors. This paper explores a possible association between 5-HT deficits and agitation in AD, using prolactin response to d,1-fenfluramine administration as a probe for 5-HT activity. METHODS: Five AD patients with agitation and 5 without agitation received a 60-mg oral dose of d,1-fenfluramine. Prolactin levels were obtained at baseline, and 2 and 3 hours following administration. RESULTS: Change in prolactin levels from baseline to 3 hours was significantly larger among the agitated than the nonagitated Alzheimer's patients. Further, there was a positive and significant correlation between change in prolactin levels from baseline and level of agitation. CONCLUSIONS: These findings suggest an association between 5-HT responsiveness and agitation in AD.
J Mintzer; O Brawman-Mintzer; D F Mirski; R Unger; P Nietert; A Meeks; R Sampson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological psychiatry     Volume:  44     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-05-04     Completed Date:  1999-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  918-21     Citation Subset:  IM    
Department of Psychiatry, Medical University of South Carolina, Charleston 29425, USA.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease* / classification,  complications,  physiopathology
Behavioral Symptoms / classification,  physiopathology
Biological Markers
Case-Control Studies
Fenfluramine / diagnostic use*
Prolactin / blood,  drug effects
Psychomotor Agitation* / etiology,  physiopathology
Serotonin / physiology*
Serotonin Agents / diagnostic use*
Reg. No./Substance:
0/Biological Markers; 0/Serotonin Agents; 458-24-2/Fenfluramine; 50-67-9/Serotonin; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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