Document Detail

Fenfluramine administered systemically or locally increases extracellular serotonin in the lateral hypothalamus as measured by microdialysis.
MedLine Citation:
PMID:  2468397     Owner:  NLM     Status:  MEDLINE    
Microdialysis was used to monitor serotonin, 5-hydroxyindoleacetic acid (5-HIAA) and the metabolites of dopamine, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the perifornical lateral hypothalamus (PFH) of freely moving rats. Systemically administered d-fenfluramine (d-FEN) increased extracellular serotonin, DOPAC and HVA, while decreasing serotonin's metabolite 5-HIAA. Local application of d-FEN directly to the hypothalamic terminal region caused large increases in extracellular serotonin and had a tendency to decrease all 3 metabolites. This effect was confirmed when d-FEN was infused locally by reverse dialysis. These results provide direct evidence that the anorectic drug d-FEN can increase extracellular serotonin in the hypothalamus in vivo and suggest a serotonergic action in the perifornical region. This finding is consistent with our report that a meal also increases serotonin in this region.
D Schwartz; L Hernandez; B G Hoebel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  482     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-06-01     Completed Date:  1989-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  261-70     Citation Subset:  IM    
Department of Psychology, Princeton University, NJ 08544.
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MeSH Terms
Dopamine / metabolism
Dose-Response Relationship, Drug
Extracellular Space / metabolism*
Fenfluramine / administration & dosage*
Hydroxyindoleacetic Acid / metabolism
Hypothalamic Area, Lateral / drug effects,  metabolism*
Rats, Inbred Strains
Serotonin / metabolism*
Time Factors
Reg. No./Substance:
458-24-2/Fenfluramine; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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