Document Detail


Femtomolar Zn(ii) affinity of minimal zinc hook peptides - a promising small tag for protein engineering.
MedLine Citation:
PMID:  23303248     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The minimal zinc hook peptide of Rad50 and its alanine mutants form highly stable Zn(ii) complexes. These peptides were successfully used as a small, efficient tag for reversible Zn(ii)-mediated protein homodimerization. The high stability, its biological consequences and potential applications in protein engineering are discussed.
Authors:
Tomasz Kochańczyk; Piotr Jakimowicz; Artur Krężel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratory of Chemical Biology, University of Wrocław, ul. Tamka 2, 50-137 Wrocław, Poland. krezel@biotech.uni.wroc.pl.
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