Document Detail

Femoral vascular occlusion and ventilation during recovery from heavy exercise.
MedLine Citation:
PMID:  8272586     Owner:  NLM     Status:  MEDLINE    
Ventilation and cardiac output subside gradually following cessation of exercise, which is commonly linked to the slow wash-out of materials from the recovering muscles. The effect of hindering the removal of the metabolic products of heavy cycle exercise on the kinetics of ventilation and gas exchange was studied in 5 subjects by occluding the femoral circulation with cuffs during the first 2 min of recovery (15 tests). Fifteen undisturbed recoveries served as controls. Compared to spontaneous recovery, circulatory obstruction induced an immediate (from the first breath) decrease in minute ventilation (VE), while end-tidal CO2 (PETCO2) as well as lactate and K+ in venous blood at forearm did not change significantly. A ventilatory deficit of 27 +/- 9 L was observed from the 2 min of occlusion. Following cuff deflation, VE rose 2-3 breaths after PETCO2 began to increase in every subject. The mechanisms of the normocapnic reduction of VE during occlusion, as well as the rise of ventilation following cuff release, are still unclear. However, these results argue against any significant role for hyperpnea-inducing intramuscular chemoreception, or point to muscular perfusion as a prerequisite of such a mechanism to operate.
P Haouzi; A Huszczuk; J Porszasz; B Chalon; K Wasserman; B J Whipp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  94     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-03     Completed Date:  1994-02-03     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  137-50     Citation Subset:  IM    
Division of Respiratory and Critical Care, Physiology and Medicine, Harbor-UCLA Medical Center, Torrance.
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MeSH Terms
Carbon Dioxide
Forearm / blood supply
Heart Rate
Lactates / blood
Lactic Acid
Leg / blood supply*
Potassium / blood
Tidal Volume
Reg. No./Substance:
0/Lactates; 124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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