Document Detail

Femoral and coronary angiographic trials.
MedLine Citation:
PMID:  8434557     Owner:  NLM     Status:  MEDLINE    
A number of large-scale clinical trials have demonstrated that lipid-altering therapy is associated with a reduced risk of coronary artery disease events. The mechanism of benefit has been postulated to be related to favorable effects at the level of the arterial wall. Angiography allows direct examination of the effects of lipid-altering therapy on the arterial wall and extensive angiographic trial data are now available. Coronary angiographic trials, employing various patient populations, therapies and endpoint measures, have demonstrated slowed progression and increased regression of atherosclerosis in the coronary tree. Femoral artery trials (which might be considered as surrogate for coronary artery trials) have also shown significant regression of atherosclerosis in treated patients. There are pros and cons for all of the various atherosclerosis change measurement techniques, but coronary artery disease events remain the "bottom line" of concern. In this regard, the Program on the Surgical Control of the Hyperlipidemias (POSCH) trial is valuable since the 3-year human consensus panel-derived global coronary change score predicted subsequent coronary events. Yet to be determined are which quantitative coronary angiography measures predict events. Finally, given the number of therapeutic questions that remain, the most promising opportunity for future antiatherosclerosis research may lie in the use of ultrasound to evaluate changes in the carotid arteries.
L Cashin-Hemphill
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  71     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-16     Completed Date:  1993-03-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  20B-25B     Citation Subset:  AIM; IM    
University of Southern California School of Medicine, Los Angeles 90033.
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MeSH Terms
Arteriosclerosis / radiography*
Carotid Arteries / ultrasonography
Clinical Trials as Topic
Coronary Angiography*
Femoral Artery / radiography*

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