Document Detail

Femoral artery complications after cardiac catheterization: a study of patient profile.
MedLine Citation:
PMID:  19748217     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Femoral artery complications after cardiac catheterization range from simple events to severe complications requiring invasive techniques or surgery with significant economic costs. This study evaluated early femoral arterial complications from percutaneous arterial access during diagnostic and interventional cardiac catheterizations in an era of widespread use of closure devices and intense anticoagulation. METHODS: Patients undergoing percutaneous cardiac catheterization via the femoral artery between August 2005 and December 2005 were identified using an ICD-9 patient database. Forty-six data points were extracted by retrospective chart review, including demographics, comorbidities, type of anticoagulation, procedural details, and postprocedural complications. Univariable analysis and binary logistic regression were used to determine factors associated with complications. RESULTS: Eighty-two of 579 patients (14%) suffered complications. The most common complications were hematomas (51 patients, 10%) and active bleeding (14 patients, 2.4%). Closure devices were used in 470 patients. After multivariable correction, use of preprocedural (odds ratio [OR]=5.65, 95% confidence interval [CI] 2.58-12.3, p<0.001) and intraprocedural (OR=4.88, 95% CI 1.95-12.3, p<0.001) antithrombotic agents (antiplatelet and/or anticoagulants), intraprocedural clopidogrel (OR=2.98, 95% CI 1.21-7.30, p=0.017), and postprocedural heparin (OR=29.4, 95% CI 3.56-250, p=0.002) were associated with increased risk. Coronary artery disease was associated with increased risk (OR=11.1, 95% CI 4.78-25.6, p<0.001), while use of a closure device (OR=0.263, 95% CI 0.125-0.553, p<0.001), male gender (OR=0.421, 95% CI 0.220-0.805, p=0.009), and prior catheterization (OR=0.033, 95% CI 0.012-0.095, p<0.001) were protective. CONCLUSION: With increasing numbers of complex coronary endovascular procedures and widespread use of high-dose multidrug antithrombotic therapy, femoral artery injuries will continue to be a significant risk for patients. Postprocedural monitoring with a high level of suspicion and use of vascular closure devices in high-risk patients may decrease the incidence of femoral artery complications. The use of vascular closure devices after low-risk procedures in male patients or those with previous ipsilateral catheterization might not be warranted but needs further study.
Mario Castillo-Sang; Albert W Tsang; Babatunde Almaroof; James Cireddu; Joseph Sferra; Gerald B Zelenock; Milo Engoren; Gregory Kasper
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Publication Detail:
Type:  Journal Article     Date:  2009-09-11
Journal Detail:
Title:  Annals of vascular surgery     Volume:  24     ISSN:  1615-5947     ISO Abbreviation:  Ann Vasc Surg     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703941     Medline TA:  Ann Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  328-35     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Annals of Vascular Surgery Inc. Published by Elsevier Inc. All rights reserved.
The University of Toledo Health Science Campus, Toledo, OH 43614, USA.
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MeSH Terms
Anticoagulants / adverse effects
Coronary Artery Disease / complications
Femoral Artery*
Heart Catheterization / adverse effects*
Hematoma / etiology*,  therapy
Hemorrhage / etiology*,  therapy
Hemostatic Techniques / instrumentation
Heparin / adverse effects
Logistic Models
Middle Aged
Odds Ratio
Platelet Aggregation Inhibitors / adverse effects
Punctures / adverse effects
Retrospective Studies
Risk Assessment
Risk Factors
Sex Factors
Ticlopidine / adverse effects,  analogs & derivatives
Reg. No./Substance:
0/Anticoagulants; 0/Platelet Aggregation Inhibitors; 55142-85-3/Ticlopidine; 9005-49-6/Heparin; 90055-48-4/clopidogrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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