Document Detail


Female-specific issues in multiple sclerosis.
MedLine Citation:
PMID:  18505361     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Complex neuroendocrine mechanisms regulating the immune response can be recognized in all autoimmune diseases. Such mechanisms develop through endocrine loops and feedback processes along the hypothalamus-pituitary-gonads axis and the hypothalamus-pituitary- adrenal gland axis. Females are not only more susceptible to autoimmune diseases, but are also more exposed to relevant variations of hormonal levels that physiologically go along with women's life. This paper reviews female-specific issues in multiple sclerosis and how treatments must be considered accordingly. In particular, aspects related to puberty, menses, fertility, pregnancy, lactation and menopause are considered in addition to epidemiological and clinical issues.
Authors:
Angelo Ghezzi; Mauro Zaffaroni
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of neurotherapeutics     Volume:  8     ISSN:  1744-8360     ISO Abbreviation:  Expert Rev Neurother     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-28     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101129944     Medline TA:  Expert Rev Neurother     Country:  England    
Other Details:
Languages:  eng     Pagination:  969-77     Citation Subset:  IM    
Affiliation:
Centro Studi Sclerosi Multipla Via Pastori, 4, I-21013 Gallarate, Italy. centro.sm@aogallarate.it
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MeSH Terms
Descriptor/Qualifier:
Autoimmune Diseases / complications*,  diagnosis,  therapy*
Female
Humans
Multiple Sclerosis / complications*,  diagnosis,  therapy*
Women's Health*

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