Document Detail

Female sex is associated with increased mortality and morbidity early, but not late, after coronary artery bypass grafting.
MedLine Citation:
PMID:  8880029     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe mortality and morbidity during a period of 2 years after coronary artery bypass grafting in relation to gender. DESIGN: Prospective follow-up study. SETTING: Two regional cardiothoracic centres which performed all the coronary artery bypass operations in western Sweden at the time. SUBJECTS: A total of 2129 (1727 (81%) men and 402 (19%) women) consecutive patients undergoing coronary artery bypass surgery between June 1988 and June 1991 without concomitant procedures. RESULTS: Females were older and more frequently had a history of hypertension, diabetes mellitus, congestive heart failure, renal dysfunction and obesity. In a multivariate analysis, taking account of age, history of cardiovascular diseases and renal dysfunction, female sex appeared as a significant independent predictor of mortality during the 30 days after coronary artery bypass grafting (P < 0.05), but not thereafter. Various postoperative complications including neurological deficit, hydro- and pneumo-thorax, perioperative myocardial damage and the need for assist devices and prolonged reperfusion were more common in females than males. CONCLUSION: Females run an increased risk of early death and the development of postoperative complications after coronary artery bypass surgery as compared with males. Late mortality does not appear to be influenced by gender and the long-term benefit of the coronary artery bypass graft operation is similar in men and women.
G Brandrup-Wognsen; H Berggren; M Hartford; A Hjalmarson; T Karlsson; J Herlitz
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European heart journal     Volume:  17     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-30     Completed Date:  1997-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1426-31     Citation Subset:  IM    
Division of Thoracic and Cardiovascular Surgery, Sahlgrenska University Hospital, Göteborg, Sweden.
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MeSH Terms
Coronary Artery Bypass / mortality*
Data Collection
Follow-Up Studies
Middle Aged
Multivariate Analysis
Postoperative Complications / epidemiology*,  physiopathology
Proportional Hazards Models
Prospective Studies
Risk Factors
Sex Factors
Survival Rate
Time Factors
Comment In:
Eur Heart J. 1997 Apr;18(4):699   [PMID:  9129906 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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