Document Detail

Female reproductive properties and prenatal development of a senescence-accelerated mouse strain.
MedLine Citation:
PMID:  7622993     Owner:  NLM     Status:  MEDLINE    
Female reproductive properties, early embryonic development, and serum estradiol and progesterone levels of the senescence-accelerated mouse (SAM)-prone (SAM-P) strain were compared with those of a SAM-resistant (SAM-R) strain. The reproductive life span of SAM-P (from 11.4 to 25.0 weeks old) was shorter than that of SAM-R (11.1 to 41.6 weeks old), and the total number of SAM-P pups was 41.7% less than from SAM-R. The reproductive senescence of SAM-P is more accelerated than that of SAM-R. At 15 weeks old, the maximum litter size of SAM-P was noted and was 33.7% smaller than that of SAM-R. Although no differences in the numbers of ovulated and fertilized ova were observed between two strains, the number of implants in SAM-P was 21.6% less than in SAM-R. Cell cleavage was delayed in embryos of SAM-P (8% morula, at day 2 of pregnancy) compared to SAM-R (48%). At day 3 of pregnancy, 9% and 33% of the embryos were blastocysts in SAM-P and SAM-R, respectively. At day 1 of pregnancy, serum estradiol level in SAM-P was 18.2% higher than in SAM-R, whereas the serum progesterone level in SAM-P was 46.2% lower than in SAM-R. The unbalance of estradiol and progesterone levels in SAM-P was considered to be the cause of the delay in early embryonic development, and then the decrease of implantation and a smaller litter size.
H Miyamoto; N Manabe; Y Mitani; N Sugimoto; T Watanabe; C Aruga; E Sato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of experimental zoology     Volume:  272     ISSN:  0022-104X     ISO Abbreviation:  J. Exp. Zool.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-08-31     Completed Date:  1995-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375365     Medline TA:  J Exp Zool     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  116-22     Citation Subset:  IM    
Department of Animal Science, Kyoto University, Japan.
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MeSH Terms
Aging / physiology*
Embryo Implantation / physiology
Estradiol / blood
Estrus / physiology
Mice, Inbred Strains / physiology*
Progesterone / blood
Reproduction / physiology*
Reg. No./Substance:
50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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