Document Detail

Female hormones affect symptom severity in obsessive-compulsive disorder.
MedLine Citation:
PMID:  16528139     Owner:  NLM     Status:  MEDLINE    
There is circumstantial evidence that reproductive events can influence symptom severity of obsessive-compulsive disorder (OCD). We sent self-report questionnaires to 350 female outpatients with OCD to examine the relationship between the menstrual cycle, pregnancy, menopause, hormonal contraceptives, selective serotonin reuptake inhibitors and symptom severity of OCD. Yale-Brown Obsessive-Compulsive Scale scores were used at three serial time points during the menstrual cycle to assess symptom severity. One hundred and one out of 350 questionnaires (29%) were returned and completed. Forty-nine patients reported an exacerbation of OCD symptoms during the premenstrual period, nine during the menopause and 17 patients during pregnancy, whereas 11 patients mentioned improvement of OCD symptoms during pregnancy. Premenstrual dysphoric disorder could only partly explain a premenstrual exacerbation of OCD symptoms. Exacerbation of OCD could be related to reproductive events in a considerable number of patients, especially the premenstrum. Because reproductive cycle events influence the symptom severity of OCD, the menstrual cycle should be taken into account when assessing the severity of OCD symptoms during pharmacological studies.
Nienke C C Vulink; Damiaan Denys; Léonie Bus; Herman G M Westenberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International clinical psychopharmacology     Volume:  21     ISSN:  0268-1315     ISO Abbreviation:  Int Clin Psychopharmacol     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-03-10     Completed Date:  2006-10-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8609061     Medline TA:  Int Clin Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  171-5     Citation Subset:  IM    
The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
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MeSH Terms
Antidepressive Agents / pharmacology,  therapeutic use
Antipsychotic Agents / pharmacology,  therapeutic use
Clomipramine / therapeutic use
Contraceptives, Oral, Hormonal / pharmacology,  therapeutic use
Depression, Postpartum / physiopathology
Drug Therapy, Combination
Gonadal Steroid Hormones / physiology*
Menopause / physiology
Menstrual Cycle / physiology
Middle Aged
Obsessive-Compulsive Disorder / pathology,  physiopathology*
Premenstrual Syndrome / drug therapy,  physiopathology
Reproducibility of Results
Serotonin Uptake Inhibitors / therapeutic use
Severity of Illness Index
Withholding Treatment
Reg. No./Substance:
0/Antidepressive Agents; 0/Antipsychotic Agents; 0/Contraceptives, Oral, Hormonal; 0/Gonadal Steroid Hormones; 0/Serotonin Uptake Inhibitors; 303-49-1/Clomipramine

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