Document Detail


Female spontaneously hypertensive rats have greater renal anti-inflammatory T lymphocyte infiltration than males.
MedLine Citation:
PMID:  22761180     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T cells contribute to hypertension in male experimental models; data in females is lacking even though women are more likely to develop immune disorders. The goal of this study was to determine whether immune cells contribute to hypertension in female spontaneously hypertensive rats (SHR) and define the T cell profile in whole blood and kidneys of male and female SHR. We hypothesized that inflammatory cells contribute to hypertension in female SHR; however, male SHR have a higher blood pressure so we hypothesize they will have a heightened inflammatory profile. The lymphocyte inhibitor mycophenolate mofetil (MMF) was administered in a dose-dependent manner to SHR. At the highest dose (50 mg·kg(-1)·day(-1)), blood pressure was significantly decreased in both sexes, yet the percent decrease in blood pressure was greater in females (female: 12 ± 1%; males: 7 ± 1%, P = 0.01). Circulating and renal T cell profiles were defined using analytical flow cytometry. Female SHR had more circulating CD3(+), CD4(+), and pro-inflammatory CD3(+)CD4(+)RORγ(+) Th17 cells, whereas males had more immune-suppressive CD3(+)CD4(+)Foxp3(+) T regulatory cells. In the kidney, females had greater numbers of CD8(+) and T regulatory cells than males, whereas males had greater CD4(+) and Th17 cell infiltration. MMF decreased circulating and renal T cells in both sexes (P < 0.0001), although the effect of MMF on T cell subtypes was sex specific with females having greater sensitivity to MMF-induced decreases in lymphocytes. In conclusion, there is a lymphocyte contribution to the maintenance of hypertension in the female SHR and sex of the animal impacts the T cell profile.
Authors:
Ashlee J Tipton; Babak Baban; Jennifer C Sullivan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2012-07-03
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  303     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-16     Completed Date:  2012-11-06     Revised Date:  2013-10-11    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R359-67     Citation Subset:  IM    
Affiliation:
Department of Medicine, Georgia Health Sciences University, Augusta, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*,  physiology
Female
Hypertension / immunology*,  pathology
Immunosuppressive Agents / pharmacology
Kidney / drug effects,  immunology*,  pathology
Male
Mycophenolic Acid / analogs & derivatives,  pharmacology
Rats
Rats, Inbred SHR
Sex Factors
T-Lymphocytes / drug effects,  immunology*,  pathology
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid; 9242ECW6R0/mycophenolate mofetil
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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