| Felypressin, but not epinephrine, reduces myocardial oxygen tension after an injection of dental local anesthetic solution at routine doses. | |
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MedLine Citation:
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PMID: 20031290 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study was to evaluate the effect of epinephrine (Epi) or felypressin (Fely) contained in dental local anesthetics on myocardial oxygen balance. MATERIALS AND METHODS: Male Japanese White tracheotomized rabbits were anesthetized with isoflurane. Three doses of 0.18, 0.36, and 0.72 mL of 2% lidocaine hydrochloride containing 1:80,000 Epi or 3% prilocaine hydrochloride containing Fely 0.03 IU/mL were injected into the rabbit tongue muscle. These doses were equivalent to 2, 4, and 8 of dental local anesthetic cartridges in humans weighing 50 kg by body weight correction, respectively. Heart rate, blood pressure, aortic blood flow, myocardial tissue blood flow, and myocardial tissue oxygen tension were continuously monitored. Data were recorded immediately before and 10, 20, 30, and 60 minutes after the injection. RESULTS: Heart rate decreased in the Fely group. Systolic blood pressure increased in the Epi group, and diastolic blood pressure increased in both groups. Aortic blood flow and myocardial tissue blood flow increased, whereas myocardial tissue oxygen tension did not change in the Epi group. In contrast, aortic blood flow, myocardial tissue blood flow, and myocardial tissue oxygen tension decreased in the Fely group. CONCLUSION: It is suggested that Fely, but not Epi, decreases myocardial oxygen tension and aggravates myocardial oxygen demand/supply balance even after an injection of dental local anesthetic solution at routine doses. |
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Authors:
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Motoaki Inagawa; Tatsuya Ichinohe; Yuzuru Kaneko |
Publication Detail:
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Type: Journal Article Date: 2009-12-23 |
Journal Detail:
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Title: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons Volume: 68 ISSN: 1531-5053 ISO Abbreviation: J. Oral Maxillofac. Surg. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8206428 Medline TA: J Oral Maxillofac Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1013-7 Citation Subset: AIM; D; IM |
Copyright Information:
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Copyright 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan. motoakick1@mac.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Local
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administration & dosage* Animals Aorta / drug effects Blood Pressure / drug effects Coronary Circulation / drug effects Dose-Response Relationship, Drug Epinephrine / administration & dosage* Felypressin / administration & dosage* Heart / drug effects* Heart Rate / drug effects Injections Lidocaine / administration & dosage Male Myocardium / metabolism Oxygen Consumption / drug effects* Prilocaine / administration & dosage Rabbits Regional Blood Flow / drug effects Tongue / drug effects Vasoconstrictor Agents / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Vasoconstrictor Agents; 137-58-6/Lidocaine; 51-43-4/Epinephrine; 56-59-7/Felypressin; 721-50-6/Prilocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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