| Felodipine (once daily) versus nifedipine (four times daily) for Prinzmetal's angina pectoris. | |
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MedLine Citation:
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PMID: 1746458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 30 consecutive patients with Prinzmetal's angina pectoris, the antiischemic effect of felodipine, a new long-acting vasoselective calcium antagonist, administered at doses of 10 and 20 mg once daily was compared with that of the well-established therapeutic regimen with nifedipine administered at a dose of 20 mg 4 times daily. Twenty-four-hour Holter monitoring was performed during a 2-day placebo run-in and at the end of each of 3 consecutive 6-day periods during which the 3 active treatments were administered in randomized sequence. Three patients withdrew, whereas 27 completed the study. The therapeutic regimens tested proved to be similarly effective; primary end points (ischemic episodes recorded by Holter monitoring, and anginal attacks reported on diary cards) occurred in 5 patients (19%) during nifedipine treatment, and in 7 (26%) and 3 (11%) during felodipine treatment with 10 and 20 mg, respectively (p = not significant). The distribution of residual ischemic episodes demonstrated that treatment with felodipine once daily provides 24-hour antiischemic protection. Twenty-six patients were followed up with 20 mg of felodipine once daily for a mean of 6 +/- 5 months, and 21 of them (81%) remained free of symptoms and Holter-recorded ischemic attacks. It is concluded that for Prinzmetal's angina pectoris, 24-hour antiischemic protection may be achieved with administration of felodipine once daily. The availability of a simplified therapeutic approach may constitute a real advantage in terms of patient compliance and improving the quality of life. |
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Authors:
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D Ardissino; S Savonitto; A Mussini; P Zanini; A Rolla; P Barberis; M Sardina; G Specchia |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of cardiology Volume: 68 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-01-16 Completed Date: 1992-01-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1587-92 Citation Subset: AIM; IM |
Affiliation:
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Divisione di Cardiologia, Policlinico San Matteo, Università degli Studi di Pavia, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angina Pectoris, Variant
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drug therapy*,
physiopathology Coronary Angiography Coronary Disease / physiopathology Double-Blind Method Electrocardiography, Ambulatory / drug effects Felodipine / administration & dosage, blood, therapeutic use* Female Follow-Up Studies Humans Male Middle Aged Nifedipine / administration & dosage, blood, therapeutic use* Placebos Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Placebos; 21829-25-4/Nifedipine; 72509-76-3/Felodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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