Document Detail

Felodipine, blood pressure, and cardiovascular reflexes in hypertensive humans.
MedLine Citation:
PMID:  3539796     Owner:  NLM     Status:  MEDLINE    
The influence of acute and chronic treatment with felodipine on ambulatory intra-arterial blood pressure, certain cardiac reflexes, and plasma renin activity was studied in nine patients with essential hypertension. Acute oral administration of the drug caused a significant reduction in blood pressure associated with an increase in heart rate mediated by the sinoaortic baroreceptor-heart rate reflex. After 1 week of treatment reflex resetting had occurred, returning heart rate to normal despite continuing blood pressure reduction. This effect was maintained throughout 6 weeks of treatment. Withdrawal of treatment was followed by return of the blood pressure to control levels associated with significant bradycardia caused by reflex reactivation at its reset level. No change was observed in response to tilting or Valsalva's maneuver or in plasma renin activity. Ambulatory intra-arterial data suggested that the clinically useful antihypertensive action of felodipine persists for 9 hours.
S A Smith; P J Mace; W A Littler
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  8     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-01-29     Completed Date:  1987-01-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1172-8     Citation Subset:  IM    
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects*
Heart Rate / drug effects
Hypertension / drug therapy*,  physiopathology
Middle Aged
Nitrendipine / analogs & derivatives*,  therapeutic use
Pressoreceptors / physiology
Reflex / drug effects*
Renin / blood
Time Factors
Reg. No./Substance:
0/Antihypertensive Agents; 39562-70-4/Nitrendipine; 72509-76-3/Felodipine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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