| Felodipine, blood pressure, and cardiovascular reflexes in hypertensive humans. | |
MedLine Citation:
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PMID: 3539796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of acute and chronic treatment with felodipine on ambulatory intra-arterial blood pressure, certain cardiac reflexes, and plasma renin activity was studied in nine patients with essential hypertension. Acute oral administration of the drug caused a significant reduction in blood pressure associated with an increase in heart rate mediated by the sinoaortic baroreceptor-heart rate reflex. After 1 week of treatment reflex resetting had occurred, returning heart rate to normal despite continuing blood pressure reduction. This effect was maintained throughout 6 weeks of treatment. Withdrawal of treatment was followed by return of the blood pressure to control levels associated with significant bradycardia caused by reflex reactivation at its reset level. No change was observed in response to tilting or Valsalva's maneuver or in plasma renin activity. Ambulatory intra-arterial data suggested that the clinically useful antihypertensive action of felodipine persists for 9 hours. |
Authors:
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S A Smith; P J Mace; W A Littler |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Hypertension Volume: 8 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1986 Dec |
Date Detail:
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Created Date: 1987-01-29 Completed Date: 1987-01-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1172-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / therapeutic use* Blood Pressure / drug effects* Felodipine Female Heart Rate / drug effects Humans Hypertension / drug therapy*, physiopathology Male Middle Aged Nitrendipine / analogs & derivatives*, therapeutic use Pressoreceptors / physiology Reflex / drug effects* Renin / blood Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 39562-70-4/Nitrendipine; 72509-76-3/Felodipine; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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