Document Detail

Fellow travellers: emergent properties of collective cell migration.
MedLine Citation:
PMID:  23059978     Owner:  NLM     Status:  MEDLINE    
Cells can migrate individually or collectively. Collective movement is common during normal development and is also a characteristic of some cancers. This review discusses recent insights into features that are unique to collective cell migration, as well as properties that emerge from these features. The first feature is that cells of the collective affect each other through adhesion, force-dependent and signalling interactions. The second feature is that cells of the collective differ from one another: leaders from followers, tip from stalk and front from back. These are dynamic differences that are important for directional movement. Last, an unexpected property is discussed: epithelial cells can rotate persistently in constrained spaces.
Pernille Rørth
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-10-12
Journal Detail:
Title:  EMBO reports     Volume:  13     ISSN:  1469-3178     ISO Abbreviation:  EMBO Rep.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-06     Completed Date:  2013-07-29     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  984-91     Citation Subset:  IM    
Institute of Molecular & Cell Biology, 61 Biopolis Drive, Singapore 138673, and Department of Biological Sciences, The National University of Singapore, Singapore 117604.
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MeSH Terms
Cell Adhesion
Cell Communication
Cell Movement*
Epithelial Cells / metabolism,  physiology*
Extracellular Matrix / metabolism

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