Document Detail


Feline maternal taurine deficiency: effect on mother and offspring.
MedLine Citation:
PMID:  3754276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adult female cats were fed a defined purified diet (taurine-free) either alone or supplemented with 0.05% taurine for at least 6 mo prior to breeding. The reproductive performance by the taurine-depleted females was poor, whereas those receiving dietary taurine had normal pregnancies and deliveries. The taurine-depleted females suffered from severe retinal degeneration, including a large loss of photoreceptor outer segments, and degeneration of the tapetum lucidum, and greatly reduced concentrations of taurine in their body tissues and fluids. Surviving offspring from the taurine-depleted mothers exhibited a number of neurological abnormalities and substantially reduced concentrations of taurine in the body tissues and fluids. Except for greater concentrations of cystathionine in neural tissues, other free amino acids in tissues were unaffected. The specific activities of a number of enzymes involved in the biosynthesis of taurine were unchanged in liver and brain. The composition of maternal milk, total protein, protein amino acids and free amino acids was unchanged except for taurine content, suggesting that the abnormalities in the offspring resulted from the diminished dietary taurine.
Authors:
J A Sturman; A D Gargano; J M Messing; H Imaki
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  116     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-05-22     Completed Date:  1986-05-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  655-67     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism
Animal Nutritional Physiological Phenomena
Animals
Carboxy-Lyases / metabolism
Cats / embryology,  metabolism*
Cystathionine beta-Synthase / metabolism
Cystathionine gamma-Lyase / metabolism
Cysteine Dioxygenase
Dioxygenases*
Eye / drug effects,  pathology,  ultrastructure
Female
Maternal-Fetal Exchange
Milk / metabolism
Milk Proteins / metabolism
Nutritional Requirements
Oxygenases / metabolism
Pregnancy
Pregnancy Complications / metabolism*
Taurine / deficiency*,  metabolism
Grant Support
ID/Acronym/Agency:
HD-16634/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Milk Proteins; 107-35-7/Taurine; EC 1.13.-/Oxygenases; EC 1.13.11.-/Dioxygenases; EC 1.13.11.20/Cysteine Dioxygenase; EC 4.1.1.-/Carboxy-Lyases; EC 4.1.1.29/sulfoalanine decarboxylase; EC 4.2.1.22/Cystathionine beta-Synthase; EC 4.4.1.1/Cystathionine gamma-Lyase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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