| Feline maternal taurine deficiency: effect on mother and offspring. | |
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MedLine Citation:
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PMID: 3754276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adult female cats were fed a defined purified diet (taurine-free) either alone or supplemented with 0.05% taurine for at least 6 mo prior to breeding. The reproductive performance by the taurine-depleted females was poor, whereas those receiving dietary taurine had normal pregnancies and deliveries. The taurine-depleted females suffered from severe retinal degeneration, including a large loss of photoreceptor outer segments, and degeneration of the tapetum lucidum, and greatly reduced concentrations of taurine in their body tissues and fluids. Surviving offspring from the taurine-depleted mothers exhibited a number of neurological abnormalities and substantially reduced concentrations of taurine in the body tissues and fluids. Except for greater concentrations of cystathionine in neural tissues, other free amino acids in tissues were unaffected. The specific activities of a number of enzymes involved in the biosynthesis of taurine were unchanged in liver and brain. The composition of maternal milk, total protein, protein amino acids and free amino acids was unchanged except for taurine content, suggesting that the abnormalities in the offspring resulted from the diminished dietary taurine. |
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Authors:
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J A Sturman; A D Gargano; J M Messing; H Imaki |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of nutrition Volume: 116 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-05-22 Completed Date: 1986-05-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 655-67 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism Animal Nutritional Physiological Phenomena Animals Carboxy-Lyases / metabolism Cats / embryology, metabolism* Cystathionine beta-Synthase / metabolism Cystathionine gamma-Lyase / metabolism Cysteine Dioxygenase Dioxygenases* Eye / drug effects, pathology, ultrastructure Female Maternal-Fetal Exchange Milk / metabolism Milk Proteins / metabolism Nutritional Requirements Oxygenases / metabolism Pregnancy Pregnancy Complications / metabolism* Taurine / deficiency*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HD-16634/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Milk Proteins; 107-35-7/Taurine; EC 1.13.-/Oxygenases; EC 1.13.11.-/Dioxygenases; EC 1.13.11.20/Cysteine Dioxygenase; EC 4.1.1.-/Carboxy-Lyases; EC 4.1.1.29/sulfoalanine decarboxylase; EC 4.2.1.22/Cystathionine beta-Synthase; EC 4.4.1.1/Cystathionine gamma-Lyase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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