Document Detail

Feline leukemia virus-induced immunodeficiency syndrome in cats as a model for evaluation of antiretroviral therapy.
MedLine Citation:
PMID:  2540109     Owner:  NLM     Status:  MEDLINE    
Severe progressive immunodeficiency syndrome can be induced experimentally with a molecularly cloned isolate of feline leukemia virus (FeLV-FAIDS). The resultant disease syndrome is characterized by persistent viremia, lymphopenia, progressive weight loss, persistent diarrhea, enteropathy, and opportunistic infections. The onset of clinical immunodeficiency disease is prefigured by the replication of the FeLV-FAIDS variant virus in bone marrow and other tissues. The FeLV-FAIDS system can be used to evaluate antiviral agents which act on steps in the replication cycle which are conserved among retroviruses (e.g. reverse transcriptase, protease, assembly). The persistence and magnitude of viremia serves as a useful parameter in antiviral studies because it can be easily measured, presages the eventual development of immunodeficiency, and provides a convenient indicator of therapeutic efficacy either in preventing de novo FeLV infection or in reversing or ameliorating established infection. We describe here the evaluation of 2',3'-dideoxycytidine (ddC) against FeLV-FAIDS infection - both in vitro in cell culture assay systems and in vivo in cats administered ddC either via intravenous bolus dosage or via controlled release subcutaneous implants. We found that, although controlled release delivery of ddC inhibited de novo FeLV-FAIDS replication and delayed onset of viremia when therapy was discontinued (after 3 weeks), an equivalent incidence and level of viremia were established rapidly in both ddC-treated and control cats. The FeLV model, therefore, can be used to assess rapidly experimental single agent or combined antiviral therapies for persistent retrovirus infection and disease.
E A Hoover; N S Zeidner; N A Perigo; S L Quackenbush; J D Strobel; D L Hill; J I Mullins
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Intervirology     Volume:  30 Suppl 1     ISSN:  0300-5526     ISO Abbreviation:  Intervirology     Publication Date:  1989  
Date Detail:
Created Date:  1989-05-26     Completed Date:  1989-05-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0364265     Medline TA:  Intervirology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  12-25     Citation Subset:  IM; X    
Department of Pathology, Colorado State University, Fort Collins 80523.
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MeSH Terms
Acquired Immunodeficiency Syndrome / drug therapy*
Cell Line
Cytopathogenic Effect, Viral
Delayed-Action Preparations
Dideoxynucleosides / administration & dosage,  therapeutic use*
Disease Models, Animal*
Drug Evaluation, Preclinical
Drug Implants
Drug Therapy, Combination
Immunologic Deficiency Syndromes / drug therapy*
Injections, Intravenous
Injections, Subcutaneous
Leukemia Virus, Feline / drug effects
Leukemia, Experimental / drug therapy
Retroviridae Infections / drug therapy
Specific Pathogen-Free Organisms
Tetrahydrouridine / therapeutic use
Viremia / drug therapy
Grant Support
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Dideoxynucleosides; 0/Drug Implants; 18771-50-1/Tetrahydrouridine; 7481-89-2/Zalcitabine

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