Document Detail

Feline immunodeficiency virus associated myopathy in the adult cat.
MedLine Citation:
PMID:  9843069     Owner:  NLM     Status:  MEDLINE    
Human immunodeficiency virus (HIV-1) associated myopathy can be a debilitating disease in humans, leading to weakness, myalgia, and muscle wasting. Subclinical neuromuscular involvement is also common. A range of histologic lesions have been described in both forms that include both inflammatory and degenerative changes. The purpose of this study was to determine whether a myopathy was present in adult cats experimentally infected with feline immunodeficiency virus (FIV). Six specific pathogen-free, laboratory-housed cats were challenged intravenously with 1000 TCID50 of the Maryland isolate of FIV (FIV-MD) at 8 months of age. The highest serum creatine kinase values were seen at 18 months postinfection (mean 9838, SD 4805 U/L) compared to preinfection (mean 950, SD 374 U/L). Needle EMG studies revealed abnormal spontaneous activity in 2 cats. All FIV-MD infected cats exhibited at least one abnormality in muscle pathology. Of the 24 muscle samples, 15 (63%) had histopathologic lesions. The predominant histologic abnormalities consisted of perivascular and pericapillary lymphocytic infiltration, and myofiber necrosis, phagocytosis, and regeneration. Lymphocytic infiltration was graded 2+ or higher in 12 of 24 muscle samples (0 = negligible; 4+ = extensive). Immunohistochemical phenotypic lymphocyte labeling in all cats demonstrated only CD8+ lymphocyte staining. This report demonstrates the presence of a FIV associated inflammatory myopathy in the adult cat. Several similarities are apparent in comparison to HIV-1 associated polymyositis reported in humans. Future studies in the cat may thus prove useful in elucidating the pathogenesis of retrovirus related myopathy in humans.
M Podell; E Chen; G D Shelton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Muscle & nerve     Volume:  21     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1998-12-23     Completed Date:  1998-12-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1680-5     Citation Subset:  IM; X    
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus 43210, USA.
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MeSH Terms
CD8-Positive T-Lymphocytes / pathology
Creatine Kinase / blood
Immunodeficiency Virus, Feline*
Lentivirus Infections*
Muscle, Skeletal / pathology
Myositis / enzymology,  pathology,  physiopathology,  virology*
Grant Support
K02 MH01400-01/MH/NIMH NIH HHS; P30CA16058/CA/NCI NIH HHS; R29 MH54939-01/MH/NIMH NIH HHS
Reg. No./Substance:
EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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