Document Detail


Feline immunodeficiency virus associated myopathy in the adult cat.
MedLine Citation:
PMID:  9843069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human immunodeficiency virus (HIV-1) associated myopathy can be a debilitating disease in humans, leading to weakness, myalgia, and muscle wasting. Subclinical neuromuscular involvement is also common. A range of histologic lesions have been described in both forms that include both inflammatory and degenerative changes. The purpose of this study was to determine whether a myopathy was present in adult cats experimentally infected with feline immunodeficiency virus (FIV). Six specific pathogen-free, laboratory-housed cats were challenged intravenously with 1000 TCID50 of the Maryland isolate of FIV (FIV-MD) at 8 months of age. The highest serum creatine kinase values were seen at 18 months postinfection (mean 9838, SD 4805 U/L) compared to preinfection (mean 950, SD 374 U/L). Needle EMG studies revealed abnormal spontaneous activity in 2 cats. All FIV-MD infected cats exhibited at least one abnormality in muscle pathology. Of the 24 muscle samples, 15 (63%) had histopathologic lesions. The predominant histologic abnormalities consisted of perivascular and pericapillary lymphocytic infiltration, and myofiber necrosis, phagocytosis, and regeneration. Lymphocytic infiltration was graded 2+ or higher in 12 of 24 muscle samples (0 = negligible; 4+ = extensive). Immunohistochemical phenotypic lymphocyte labeling in all cats demonstrated only CD8+ lymphocyte staining. This report demonstrates the presence of a FIV associated inflammatory myopathy in the adult cat. Several similarities are apparent in comparison to HIV-1 associated polymyositis reported in humans. Future studies in the cat may thus prove useful in elucidating the pathogenesis of retrovirus related myopathy in humans.
Authors:
M Podell; E Chen; G D Shelton
Related Documents :
7591259 - Ethnic segregation of htlv-i and htlv-ii carriers among south american native indians.
3640579 - Non-hodgkin's lymphoma, htlv-iii/lav, and htlv-iii/lav antibody in the wife of a man wi...
9062789 - Domestic cats as indicators of the presence of spotted fever and typhus group rickettsiae.
9438159 - Feline immunodeficiency virus infection--causative agent of an acquired immunodeficienc...
9375019 - Infection of cats by injection with dna of a feline immunodeficiency virus molecular cl...
7514859 - Expression of reverse transcriptase from feline immunodeficiency virus in escherichia c...
19854459 - Nipah virus entry can occur by macropinocytosis.
21986059 - Human intestinal epithelial cells are susceptible to influenza virus subtype h9n2.
6270359 - Construction and isolation of a transmissible retrovirus containing the src gene of har...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Muscle & nerve     Volume:  21     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1998-12-23     Completed Date:  1998-12-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1680-5     Citation Subset:  IM; X    
Affiliation:
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus 43210, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
CD8-Positive T-Lymphocytes / pathology
Cats
Creatine Kinase / blood
Electromyography
Immunodeficiency Virus, Feline*
Immunohistochemistry
Lentivirus Infections*
Muscle, Skeletal / pathology
Myositis / enzymology,  pathology,  physiopathology,  virology*
Grant Support
ID/Acronym/Agency:
K02 MH01400-01/MH/NIMH NIH HHS; P30CA16058/CA/NCI NIH HHS; R29 MH54939-01/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mandibular nerve involvement in diabetic polyneuropathy and chronic inflammatory demyelinating polyn...
Next Document:  Detection of hereditary neuropathy with liability to pressure palsies among patients with acute pain...