Document Detail

Feelings of exhaustion, emotional distress, and pituitary and adrenocortical hormones in borderline hypertension.
MedLine Citation:
PMID:  8793693     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine whether feelings of exhaustion and emotional distress reflecting chronic perceived stress contribute to a pattern of pituitary and adrenocortical responses that would in turn be able to distinguish borderline hypertensives from normotensive controls. DESIGN: A cross-sectional study. SETTING: Helsinki University Central Hospital. PARTICIPANTS: Twenty-one middle-aged, male borderline hypertensives (140/90 mmHg < or = blood pressure < 160/95 mmHg) and 69 healthy normotensive controls (blood pressure < 140/90 mmHg). Main outcome measures Basal pituitary-adrenocortical activity was assessed by measurements of plasma cortisol and adrenocorticotrophin concentrations during the oral glucose tolerance test. Cortisol responses to dexamethasone suppression and adrenocorticotrophin stimulation tests were measured to determine the functional pituitary-adrenocortical activity. Feelings of exhaustion, namely, feelings of excess fatigue, loss of energy, increased irritability, demoralization and emotional distress were measured using a questionnaire. RESULTS: As has previously been shown, feelings of exhaustion and emotional distress are associated with a hormonal pattern consisting primarily of an elevation in cortisol response to adrenocorticotrophin stimulation and secondarily of dominance of cortisol in the ratio of mean basal cortisol level to mean basal adrenocorticotrophin level. This particular neuroendocrine pattern, denoting a defeat type of reaction to stress, was in turn able to distinguish borderline hypertensives from normotensive controls significantly. Adjustment for age and health-related lifestyle factors including smoking, alcohol consumption and physical activity did not alter the difference found between the groups. CONCLUSIONS: The results suggest that the variance shared by feelings of exhaustion, emotional distress and pituitary-adrenocortical hormones could elucidate the mechanisms by which stress exerts its influence towards an increased risk for hypertension.
K Räikkönen; A Hautanen; L Keltikangas-Järvinen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  14     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-12-03     Completed Date:  1996-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  713-8     Citation Subset:  IM    
Department of Psychology, University of Helsinki, Finland.
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MeSH Terms
Adrenal Cortex Hormones / physiology*
Adrenocorticotropic Hormone / blood
Cross-Sectional Studies
Dexamethasone / diagnostic use
Fatigue / etiology*
Glucose Tolerance Test
Hydrocortisone / blood
Hypertension / complications*,  diagnosis,  physiopathology*
Middle Aged
Mood Disorders / complications*
Pituitary Hormones / physiology*
Self Concept
Stress, Psychological / complications
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Pituitary Hormones; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone

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