Document Detail

Feeling the squeeze: live-cell extrusion limits cell density in epithelia.
MedLine Citation:
PMID:  22632965     Owner:  NLM     Status:  In-Data-Review    
Tissues develop in confined volumes that can impose mechanical constraints on their growth, but it is unclear how cells respond to these limits to regulate tissue size and shape. Two papers show that overcrowding and cell deformation lead to the shedding of live cells to maintain homeostasis in epithelial cell sheets.
Rodrigo Fernandez-Gonzalez; Jennifer A Zallen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell     Volume:  149     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  965-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Institute of Biomaterials and Biomedical Engineering and Department of Cell and Systems Biology, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
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