| Feeding systems in Chinese hamsters. | |
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MedLine Citation:
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PMID: 6148021 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Modulation of feeding by opiates, putative satiety peptides, and dopamine was explored in the Chinese hamster, an animal that develops diabetes mellitus in certain inbred strains. Diabetic hamsters were hyperphagic relative to their nondiabetic controls, but both groups exhibited natural circadian variation in feeding. Starvation provoked hyperphagia of about 1-h duration in both groups. Naloxone and butorphanol had no effects on Chinese hamster feeding. Opiate receptor binding on Chinese hamster brains demonstrated no specific binding of naloxone or ethylketocyclazocine, but IR-dynorphin concentrations were comparable with that in rats. N-allylnormetazocine, a sigma-opiate receptor agonist, appeared to stimulate diabetic hamster feeding. Peptides reputed to have satiety effects in rats were without effect in Chinese hamsters: cholecystokinin, bombesin, somatostatin, and pancreatic polypeptide. Calcitonin limited feeding in both groups but may be nonspecific. Dopaminergic blockade by haloperidol also limited feeding, and diabetic hamsters were more sensitive to this. Although Chinese hamsters clearly can modulate their food intake when diabetic, we conclude that the opiatergic and peptidergic influences on feeding are very different from those in rats and may be of little importance. |
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Authors:
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C J Billington; J E Morley; A S Levine; G C Gerritsen |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 247 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1984 Sep |
Date Detail:
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Created Date: 1984-10-24 Completed Date: 1984-10-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R405-11 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / immunology Calcitonin / pharmacology Circadian Rhythm Cricetinae / physiology* Cyclazocine / analogs & derivatives, pharmacology Diabetes Mellitus / physiopathology Dynorphins Eating / drug effects Endorphins / immunology Ethylketocyclazocine Feeding Behavior / physiology* Haloperidol / pharmacology Mesocricetus / physiology* Naloxone / pharmacology Peptide Fragments / immunology Phenazocine / analogs & derivatives, pharmacology Sincalide / pharmacology Starvation / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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AMO-7203/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endorphins; 0/Peptide Fragments; 127-35-5/Phenazocine; 25126-32-3/Sincalide; 3572-80-3/Cyclazocine; 465-65-6/Naloxone; 52-86-8/Haloperidol; 58640-84-9/Ethylketocyclazocine; 74913-18-1/Dynorphins; 7619-35-4/SK&F 10047; 9007-12-9/Calcitonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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