Document Detail


Feeding specific glutamate surge in the rat lateral hypothalamus revealed by low-flow push-pull perfusion.
MedLine Citation:
PMID:  18377969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Substantial evidence implicates the lateral hypothalamus (LH) in the control of ingestive behavior and previous studies have found that glutamate release within the LH increases during meals. It is not known, however, whether this effect is selective for feeding, or whether similar changes are also seen during drinking. In this work, we examined this question using low-flow push-pull perfusion which allows sampling from small tissue volumes. Presentation of highly palatable solid or liquid foods to food-deprived rats resulted in an immediate increase in glutamate output of more than 200% over baseline. The response was maximal immediately after food presentation. In contrast, significant changes in glutamate output were not seen when water was presented to water-deprived animals, despite the occurrence of vigorous drinking. These findings confirm reports of feeding related glutamate release in the LH and demonstrate that this effect is specific to feeding, rather than being a general concomitant of all ingestive behaviors. The push-pull technique described here may allow the relevant region of the LH to be identified with greater precision than other methods.
Authors:
Kongthong Thongkhao-on; David Wirtshafter; Scott A Shippy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-02-21
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  89     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-04-18     Completed Date:  2008-08-06     Revised Date:  2013-05-08    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  591-7     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of Illinois at Chicago, M/C 111, Chicago, IL 60607, United States. kthong2@uic.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Drinking Behavior / physiology
Electrophoresis, Capillary
Feeding Behavior / physiology*
Food Deprivation / physiology
Glutamic Acid / physiology*
Hypothalamic Area, Lateral / physiology*
Male
Perfusion / methods
Rats
Rats, Sprague-Dawley
Water Deprivation / physiology
Grant Support
ID/Acronym/Agency:
DA20802/DA/NIDA NIH HHS; MH067971/MH/NIMH NIH HHS; R21 MH067971/MH/NIMH NIH HHS; R21 MH067971-01A1/MH/NIMH NIH HHS; R21 MH067971-02/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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