Document Detail

Feeding responses to several neuropeptide Y receptor agonists in the neonatal chick.
MedLine Citation:
PMID:  11553363     Owner:  NLM     Status:  MEDLINE    
Neuropeptide Y is one of the most potent neuropeptides known to induce feeding in animals, and has been suggested to be a physiological signal for food intake. It has been also reported that intracerebroventricular injection of neuropeptide Y stimulates feeding behavior of the neonatal chick. There are many neuropeptide Y receptor agonists that have not been investigated in feeding response of the neonatal chick. The aim of this study is to elucidate whether central injection of several neuropeptide Y receptor agonists stimulates feeding of the neonatal chick over 2 h. We found that central injections of [Leu(31), Pro(34)]neuropeptide Y, peptide YY, human pancreatic polypeptide and rat pancreatic polypeptide significantly stimulated food intake of neonatal chicks throughout the 2-h post-injection period. Neuropeptide Y-(13-36) significantly stimulated feeding at 30 min, but not thereafter. [D-Trp(32)]neuropeptide Y stimulated feeding at 60 and 120 min, but not 30 min, post-injection. Central administration of rat pancreatic polypeptide, which does not increase food intake in rats, stimulated feeding in chicks. This result reflects structural differences of the neuropeptide Y receptor subtypes and/or differences in mechanisms stimulating feeding behavior between mammals and chickens. In conclusion, neuropeptide Y receptor agonists, except for neuropeptide Y-(13-36), are potent stimulators of food intake in the neonatal chick.
R Ando; S I Kawakami; T Bungo; A Ohgushi; T Takagi; D M Denbow; M Furuse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  427     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-12     Completed Date:  2001-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  53-9     Citation Subset:  IM    
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
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MeSH Terms
Animals, Newborn
Dose-Response Relationship, Drug
Eating / drug effects*
Neuropeptide Y / analogs & derivatives,  pharmacology
Pancreatic Polypeptide / pharmacology
Peptide YY / pharmacology
Receptors, Neuropeptide Y / agonists*
Time Factors
Reg. No./Substance:
0/Neuropeptide Y; 0/Receptors, Neuropeptide Y; 106388-42-5/Peptide YY; 125580-28-1/neuropeptide Y, Leu(31)-Pro(34)-; 153549-78-1/neuropeptide Y, Trp(32)-; 59763-91-6/Pancreatic Polypeptide

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