| Feeding responses to several neuropeptide Y receptor agonists in the neonatal chick. | |
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MedLine Citation:
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PMID: 11553363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuropeptide Y is one of the most potent neuropeptides known to induce feeding in animals, and has been suggested to be a physiological signal for food intake. It has been also reported that intracerebroventricular injection of neuropeptide Y stimulates feeding behavior of the neonatal chick. There are many neuropeptide Y receptor agonists that have not been investigated in feeding response of the neonatal chick. The aim of this study is to elucidate whether central injection of several neuropeptide Y receptor agonists stimulates feeding of the neonatal chick over 2 h. We found that central injections of [Leu(31), Pro(34)]neuropeptide Y, peptide YY, human pancreatic polypeptide and rat pancreatic polypeptide significantly stimulated food intake of neonatal chicks throughout the 2-h post-injection period. Neuropeptide Y-(13-36) significantly stimulated feeding at 30 min, but not thereafter. [D-Trp(32)]neuropeptide Y stimulated feeding at 60 and 120 min, but not 30 min, post-injection. Central administration of rat pancreatic polypeptide, which does not increase food intake in rats, stimulated feeding in chicks. This result reflects structural differences of the neuropeptide Y receptor subtypes and/or differences in mechanisms stimulating feeding behavior between mammals and chickens. In conclusion, neuropeptide Y receptor agonists, except for neuropeptide Y-(13-36), are potent stimulators of food intake in the neonatal chick. |
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Authors:
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R Ando; S I Kawakami; T Bungo; A Ohgushi; T Takagi; D M Denbow; M Furuse |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 427 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-09-12 Completed Date: 2001-10-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 53-9 Citation Subset: IM |
Affiliation:
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Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Chickens Dose-Response Relationship, Drug Eating / drug effects* Humans Neuropeptide Y / analogs & derivatives, pharmacology Pancreatic Polypeptide / pharmacology Peptide YY / pharmacology Rats Receptors, Neuropeptide Y / agonists* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y; 0/Receptors, Neuropeptide Y; 106388-42-5/Peptide YY; 125580-28-1/neuropeptide Y, Leu(31)-Pro(34)-; 153549-78-1/neuropeptide Y, Trp(32)-; 59763-91-6/Pancreatic Polypeptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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