| Feeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-α in the heart of the offspring. | |
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MedLine Citation:
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PMID: 22003431 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Impaired flexibility in the use of substrates for energy production in the heart is implicated in cardiomyopathy. We investigated the effect of maternal protein restriction during pregnancy in rats on the transcription of key genes in cardiac lipid and carbohydrate metabolism in the offspring. Rats were fed protein-sufficient or protein-restricted (PR) diets during pregnancy. Triacylglycerol concentration in adult (day 105) heart was altered by maternal protein intake contingent on post-weaning fat intake and sex. mRNA Expression of peroxisomal proliferator-activated receptor (PPAR)-α and carnitine palmitoyltransferase-1 was increased by the maternal PR diet in adult, but not neonatal, offspring. PPARα promoter methylation was lower in adult and neonatal heart from PR offspring. These findings suggest that prenatal nutrition alters the future transcriptional regulation of cardiac energy metabolism in the offspring through changes in epigenetic regulation of specific genes. However, changes in gene functional changes may not be apparent in early life. |
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Authors:
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J L Slater-Jefferies; K A Lillycrop; P A Townsend; C Torrens; S P Hoile; M A Hanson; G C Burdge |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Journal of developmental origins of health and disease Volume: 2 ISSN: 2040-1752 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-10-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101517692 Medline TA: J Dev Orig Health Dis Country: - |
Other Details:
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Languages: ENG Pagination: 250-255 Citation Subset: - |
Affiliation:
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Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton, SO16 6YD, UK. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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PG/06/098/21347//British Heart Foundation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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