Document Detail

Feeding intolerance in preterm infants fed with powdered or liquid formula: a randomized controlled, double-blind, pilot study.
MedLine Citation:
PMID:  23292034     Owner:  NLM     Status:  Publisher    
Feeding intolerance (FI) is usually defined as "gastric residual volume of more than 50 % of the previous feeding volume, emesis, abdominal distension or both of these symptoms and a decrease, delay or discontinuation of enteral feedings." We aimed to compare the incidence of FI in preterm infants fed with powdered or liquid infant formula, and in a prospective, double-blind, pilot study, 78 preterm infants were randomized to receive powdered or liquid form of the same preterm infant formula. The primary outcomes were the incidence of FI in both groups. The pH of gastric fluids was measured in the fasting and postprandial periods on the seventh day of life, and gastrointestinal complications were recorded during the hospitalization period. The incidence of FI was significantly higher in infants fed with liquid formula (n = 34) when compared with infants fed with powdered formula (n = 44) [9 (26.5 %) vs 2 (4.5 %), p < 0.01, respectively]. The median fasting gastric fluid pH was significantly lower and postprandial gastric fluid pH was significantly higher than in infants fed with powdered formula (2.9 vs 3.4, p < 0.01 and 6.0 vs 5.9, p < 0.05 respectively). Infants fed with liquid formula regained birth weight significantly later than infants fed with powdered formula (9.5 vs 8.0 days, p < 0.01). Conclusion: Although the exact mechanisms are not clear, increased incidence of FI and delayed growth in the first weeks of life in preterm infants fed with liquid formula might be caused by altered gastric acidity or possible disrupted protein bioavailability due to different production and sterilization processes.
Ozge Surmeli-Onay; Ayse Korkmaz; Sule Yigit; Murat Yurdakok
Related Documents :
23623474 - Effect of hormonal contraceptives during breastfeeding on infant's milk ingestion and g...
1496944 - Prevention of perinatal transmission of the hepatitis b virus. outcome of infants in a ...
25073494 - Early vitamin k deficiency bleeding in a neonate associated with maternal crohn's disease.
24121184 - Pretreatment with an intravenous lipid emulsion increases plasma eicosapentanoic acid a...
10212074 - Randomised controlled trial of vitamin d supplementation on bone density and biochemica...
12282114 - Real wage rigidity in regional labor markets in the u.k., the u.s., and west germany.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-5
Journal Detail:
Title:  European journal of pediatrics     Volume:  -     ISSN:  1432-1076     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Hacettepe University, 06100, Ankara, Turkey,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pediatric clinical pharmacology: an introduction to a series of educational papers.
Next Document:  Improved lithium-sulfur cells with a treated carbon paper interlayer.