Document Detail


Feeding inhibition by urocortin in the rat hypothalamic paraventricular nucleus.
MedLine Citation:
PMID:  11208577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ventricular administration of urocortin (UCN) inhibits feeding, but specific site(s) of UCN action are unknown. In the current studies we examined the effect of UCN in the hypothalamic paraventricular nucleus (PVN) on feeding. We tested UCN administered into the PVN in several paradigms: deprivation-induced, nocturnal, and neuropeptide Y (NPY)-induced feeding. We compared the effect of equimolar doses of UCN and corticotrophin releasing hormone (CRH) on NPY-induced and nocturnal feeding, determined whether UCN in the PVN produced a conditioned taste aversion (CTA) and induced changes in c-Fos immunoreactivity (c-Fos-ir) after UCN and NPY administration in the PVN. UCN in the PVN significantly decreased NPY and nocturnal and deprivation-induced feeding at doses of 1, 10, and 100 pmol, respectively. UCN anorectic effects lasted longer than those attributed to CRH. Ten and thirty picomoles UCN did not induce a CTA, whereas 100 pmol UCN produced a CTA. UCN (100 pmol) in the PVN neither increased c-Fos-ir in any brain region assayed nor altered c-Fos-ir patterns resulting from PVN NPY administration. These data suggest the hypothalamic PVN as a site of UCN action.
Authors:
C Wang; M A Mullet; M J Glass; C J Billington; A S Levine; C M Kotz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  280     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-14     Completed Date:  2001-04-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R473-80     Citation Subset:  IM    
Affiliation:
Veterans Affairs Medical Center, Minneapolis, MN 55417, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / drug effects,  physiology*
Circadian Rhythm
Corticotropin-Releasing Hormone / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Energy Intake / drug effects,  physiology
Feeding Behavior / drug effects*
Food Deprivation
Genes, fos
Male
Microinjections
Neuropeptide Y / administration & dosage,  pharmacology
Paraventricular Hypothalamic Nucleus / drug effects,  physiology*
Proto-Oncogene Proteins c-fos / metabolism
Rats
Rats, Sprague-Dawley
Time Factors
Urocortins
Grant Support
ID/Acronym/Agency:
DA-03999/DA/NIDA NIH HHS; DK-50456/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Neuropeptide Y; 0/Proto-Oncogene Proteins c-fos; 0/Urocortins; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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