| Feeding inhibition by urocortin in the rat hypothalamic paraventricular nucleus. | |
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MedLine Citation:
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PMID: 11208577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ventricular administration of urocortin (UCN) inhibits feeding, but specific site(s) of UCN action are unknown. In the current studies we examined the effect of UCN in the hypothalamic paraventricular nucleus (PVN) on feeding. We tested UCN administered into the PVN in several paradigms: deprivation-induced, nocturnal, and neuropeptide Y (NPY)-induced feeding. We compared the effect of equimolar doses of UCN and corticotrophin releasing hormone (CRH) on NPY-induced and nocturnal feeding, determined whether UCN in the PVN produced a conditioned taste aversion (CTA) and induced changes in c-Fos immunoreactivity (c-Fos-ir) after UCN and NPY administration in the PVN. UCN in the PVN significantly decreased NPY and nocturnal and deprivation-induced feeding at doses of 1, 10, and 100 pmol, respectively. UCN anorectic effects lasted longer than those attributed to CRH. Ten and thirty picomoles UCN did not induce a CTA, whereas 100 pmol UCN produced a CTA. UCN (100 pmol) in the PVN neither increased c-Fos-ir in any brain region assayed nor altered c-Fos-ir patterns resulting from PVN NPY administration. These data suggest the hypothalamic PVN as a site of UCN action. |
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Authors:
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C Wang; M A Mullet; M J Glass; C J Billington; A S Levine; C M Kotz |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 280 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-14 Completed Date: 2001-04-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R473-80 Citation Subset: IM |
Affiliation:
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Veterans Affairs Medical Center, Minneapolis, MN 55417, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects, physiology* Circadian Rhythm Corticotropin-Releasing Hormone / administration & dosage, pharmacology* Dose-Response Relationship, Drug Energy Intake / drug effects, physiology Feeding Behavior / drug effects* Food Deprivation Genes, fos Male Microinjections Neuropeptide Y / administration & dosage, pharmacology Paraventricular Hypothalamic Nucleus / drug effects, physiology* Proto-Oncogene Proteins c-fos / metabolism Rats Rats, Sprague-Dawley Time Factors Urocortins |
| Grant Support | |
ID/Acronym/Agency:
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DA-03999/DA/NIDA NIH HHS; DK-50456/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y; 0/Proto-Oncogene Proteins c-fos; 0/Urocortins; 9015-71-8/Corticotropin-Releasing Hormone |
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