Document Detail


Feeding infant piglets formula with long-chain polyunsaturated fatty acids as triacylglycerols or phospholipids influences the distribution of these fatty acids in plasma lipoprotein fractions.
MedLine Citation:
PMID:  11285334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several sources of long-chain polyunsaturated fatty acids (LCP) are currently available for infant formula supplementation. These oils differ in their fatty acid composition, the chemical form of the fatty acid esters [triacylglycerols (TG) or phospholipids (PL)] and presence of other lipid components. These differences may affect LCP absorption, distribution and metabolic fate after ingestion. The purpose of the present study was to evaluate the influence of different chemical forms of dietary LCP on the composition of plasma, plasma lipoproteins, liver and jejunum in infant piglets. Thirty pigs (5 d old) were bottle-fed different diets for 4 wk: a control diet (C), a diet containing LCP as TG from tuna and fungal oils (TF-TG) or a diet containing LCP as PL from egg yolk (E-PL). We measured lipid and fatty acid composition of plasma and lipoproteins, as well as lipid composition of liver and intestinal mucosa. The arachidonic and docosahexaenoic acids in HDL-PL were significantly higher in piglets fed the E-PL diet than in those fed the TF-TG diet. Opposite results were found in the LDL-PL diet. No significant differences were found between groups in TG or cholesterol concentrations of plasma or lipoproteins. Arachidonic acid in plasma PL and cholesteryl esters was significantly higher in the E-PL group than in the TF-TG group. The chemical form in which LCP esters are present in different dietary sources influences their distribution in plasma lipoproteins. This may be important for infant nutrition and suggests that not all LCP sources may be biologically equivalent.
Authors:
L Amate; A Gil; M Ramírez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  131     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-04     Completed Date:  2001-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1250-5     Citation Subset:  IM    
Affiliation:
Research and Development Department, Abbott Laboratories, 18004 Granada, Spain. Maria.Raminez@abbott.com
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MeSH Terms
Descriptor/Qualifier:
Animal Feed*
Animals
Animals, Newborn / blood*,  growth & development
Chemical Fractionation
Energy Intake
Fatty Acids / blood
Fatty Acids, Unsaturated / administration & dosage*
Food, Formulated*
Jejunum / chemistry
Lipids / analysis,  blood
Lipoproteins / blood*,  chemistry
Liver / chemistry
Phospholipids / administration & dosage*
Swine
Triglycerides / administration & dosage*
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Lipids; 0/Lipoproteins; 0/Phospholipids; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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