Document Detail

Feeding induced by blockade of histamine H1-receptor in rat brain.
MedLine Citation:
PMID:  2895015     Owner:  NLM     Status:  MEDLINE    
Histamine antagonists were infused into the third ventricle of the cerebrum in rats. All the H1-, but none of the H2-antagonists tested, induced initial feeding during the early portion of the light phase when histamine level was highest. No periprandial drinking was observed. Ambulation increased during feeding. The effect on feeding was attenuated when brain histamine was normally low during the early portion of the dark phase, or was decreased by alpha-fluoromethylhistidine. Hypothalamic neuronal histamine may suppress food intake through H1-receptors, and diurnal fluctuations of food intake may mirror neuronal histamine levels.
T Sakata; K Fukagawa; K Fujimoto; H Yoshimatsu; T Shiraishi; H Wada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experientia     Volume:  44     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-05-12     Completed Date:  1988-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  216-8     Citation Subset:  IM    
Department of Internal Medicine I, Faculty of Medicine Kyushu University, Fukuoka, Japan.
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MeSH Terms
Brain / physiology*
Circadian Rhythm
Drinking Behavior / drug effects
Feeding Behavior / drug effects*
Histamine H1 Antagonists / pharmacology*
Histamine H2 Antagonists / pharmacology
Injections, Intraventricular
Receptors, Histamine / physiology*
Receptors, Histamine H1 / physiology*
Reg. No./Substance:
0/Histamine H1 Antagonists; 0/Histamine H2 Antagonists; 0/Receptors, Histamine; 0/Receptors, Histamine H1

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