Document Detail

Feeding effects of melanocortin ligands--a historical perspective.
MedLine Citation:
PMID:  16046247     Owner:  NLM     Status:  MEDLINE    
The process of energy homeostasis is a highly regulated process involving interacting signals between a variety of anorexigenic and orexigenic peptides, proteins and signaling molecules. The melanocortin system is an important component of this complex regulatory network. Involvement of the melanocortin pathway in the control of food intake and body weight regulation has been studied extensively in the past two decades. Previous studies that involve central administration of melanocortin molecules and examination of molecules that effect food intake in melanocortin knockout (KO) mice (MC3R, MC4R, POMC, AGRP and NPY) have been examined. In this review, we have summarized feeding studies that have resulted in the recognition of the melanocortin system as a major contributor to the complex neuroendocrine system regulating energy homeostasis.
Boman G Irani; Carrie Haskell-Luevano
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Peptides     Volume:  26     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-26     Completed Date:  2008-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1788-99     Citation Subset:  IM    
Department of Medicinal Chemistry, University of Florida, P.O. Box 100485, Gainesville, FL-32610, USA.
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MeSH Terms
Eating / drug effects*,  physiology*
Melanocortins / agonists,  antagonists & inhibitors,  metabolism*,  physiology
Receptors, Melanocortin / agonists,  antagonists & inhibitors,  metabolism*,  physiology
Grant Support
Reg. No./Substance:
0/Ligands; 0/Melanocortins; 0/Receptors, Melanocortin

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