Document Detail

Feeding effects of growth hormone-releasing factor in rats are photoperiod sensitive.
MedLine Citation:
PMID:  2504226     Owner:  NLM     Status:  MEDLINE    
By examining the influence of photoperiod, this study extended previous findings showing that centrally administered growth hormone-releasing factor (GRF) increases feeding. Rats received intracerebroventricular injections of GRF (0, 0.4, 4.0, and 40.0 pmol) during either the light or dark phase of the photocycle. GRF produced a dose-dependent increase in 90-min food intake during the light photoperiod but a dose-dependent suppression during the dark photo-period. GRF did not significantly alter 24-hr feeding or locomotor activity, and a biologically inactive analog of GRF had no effect on feeding. Possible mechanisms underlying GRF's photoperiod dependency are discussed, including a suggestion that endogenous GRF may play a role in the regulation of circadian feeding.
D Feifel; F J Vaccarino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  103     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-09-27     Completed Date:  1989-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  824-30     Citation Subset:  IM    
University of Toronto, Ontario, Canada.
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MeSH Terms
Brain / drug effects
Circadian Rhythm / drug effects*
Dose-Response Relationship, Drug
Drinking / drug effects
Eating / drug effects
Feeding Behavior / drug effects*
Growth Hormone-Releasing Hormone / pharmacology*
Hunger / drug effects
Injections, Intraventricular
Motor Activity / drug effects
Rats, Inbred Strains
Reg. No./Substance:
9034-39-3/Growth Hormone-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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