| Feeding effects of growth hormone-releasing factor in rats are photoperiod sensitive. | |
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MedLine Citation:
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PMID: 2504226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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By examining the influence of photoperiod, this study extended previous findings showing that centrally administered growth hormone-releasing factor (GRF) increases feeding. Rats received intracerebroventricular injections of GRF (0, 0.4, 4.0, and 40.0 pmol) during either the light or dark phase of the photocycle. GRF produced a dose-dependent increase in 90-min food intake during the light photoperiod but a dose-dependent suppression during the dark photo-period. GRF did not significantly alter 24-hr feeding or locomotor activity, and a biologically inactive analog of GRF had no effect on feeding. Possible mechanisms underlying GRF's photoperiod dependency are discussed, including a suggestion that endogenous GRF may play a role in the regulation of circadian feeding. |
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Authors:
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D Feifel; F J Vaccarino |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Behavioral neuroscience Volume: 103 ISSN: 0735-7044 ISO Abbreviation: Behav. Neurosci. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-09-27 Completed Date: 1989-09-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302411 Medline TA: Behav Neurosci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 824-30 Citation Subset: IM |
Affiliation:
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University of Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects Circadian Rhythm / drug effects* Dose-Response Relationship, Drug Drinking / drug effects Eating / drug effects Feeding Behavior / drug effects* Growth Hormone-Releasing Hormone / pharmacology* Hunger / drug effects Injections, Intraventricular Male Motor Activity / drug effects Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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9034-39-3/Growth Hormone-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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